Salmon Calcitonin Attenuates Degenerative Modifications in Cartilage and Subchondral Bone in Lumbar Aspect Joint in an Experimental Rat Mannequin.
Med Sci Monit. 2018 Might 07;24:2849-2857
Authors: Gou Y, Tian F, Kong Q, Chen T, Li H, Lv Q, Zhang L
BACKGROUND Aspect joint degeneration (FJD) is likely one of the widespread causes of low again ache (LBP), and estrogen deficiency is likely one of the triggers for FJD. Calcitonin might possess the potential for treating osteoarthritis, however to this point the hormone has not been studied within the remedy of FJD. Due to this fact, the purpose of this examine was to analyze the consequences of salmon calcitonin (sCT) on FJD induced by estrogen deficiency after ovariectomy (OVX). MATERIAL AND METHODS Thirty feminine Sprague-Dawley rats had been randomly assigned to three teams: the OVX group obtained bilateral OVX, the OVX + sCT group obtained subcutaneous administration of sCT (16 IU/kg/2 days) following bilateral OVX, and the Sham group obtained sham surgical procedure. All rats had been euthanized at 12 weeks post-OVX. Serum COMP degree, cartilage degradation, and subchondral bone micro-architecture had been evaluated. RESULTS sCT relieved cartilage floor lesions, diminished histological rating, and considerably elevated cartilage thickness. The OVX + sCT group exhibited considerably elevated expression of aggrecan, in addition to considerably decreased ranges of ADAMTS-Four, MMP-13, and caspase-Three. The outcomes of micro-computed tomography evaluation revealed that the OVX + sCT group exhibited increased BMD, BV/TV, and Tb.Th values however a decrease Tb.Sp worth than that of the OVX group. Serum COMP concentrations had been considerably correlated with histological rating and cartilage thickness. CONCLUSIONS sCT can inhibit the development of FJD in OVX rats, which is attributed to its inhibitory results on cartilage metabolism imbalance, chondrocyte apoptosis, and subchondral bone transforming. Serum COMP has diagnostic potential for FJD.
PMID: 29748528 [PubMed – in process]