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Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study – Lumbar Fusion

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The article presents the results of a prospective pilot clinical study that evaluated the safety and efficacy of using an autologous vertebral bone marrow aspirate (vBMA) clot as a bioscaffold in instrumented posterior lumbar fusion. Ten patients undergoing multilevel posterior spinal fusion were treated with vBMA and assessed using clinical outcomes measures such as pain and disability scores. The results showed a successful fusion rate of approximately 100% at the 12-month follow-up, along with an increase in bone density. Furthermore, an improvement in the quality of life and health status of patients was observed post-surgery. No adverse events related to the vBMA clot were reported. Overall, the study demonstrates the effectiveness and safety profile of vBMA clot as a bioscaffold for posterior lumbar fusion and lays the foundation for future larger clinical studies

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

: This prospective pilot study demonstrates the effectiveness and safety profile of vBMA clot as an advanced bioscaffold capable of achieving posterior lumbar fusion in the treatment of degenerative spine diseases. This lays the groundwork for a larger randomized clinical study.

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Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.ABSTRACTBACKGROUND: Bone marrow aspirate (BMA), when combined with graft substitutes, has long been introduced as a promising alternative to iliac crest bone graft in spinal fusion. However, the use of BMA is limited by the absence of a standardized procedure, a structural texture, and the potential,

Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.

ABSTRACT

BACKGROUND: Bone marrow aspirate (BMA), when combined with graft substitutes, has long been introduced as a promising alternative to iliac crest bone graft in spinal fusion. However, the use of BMA is limited by the absence of a standardized procedure, a structural texture, and the potential for diffusion away from the implant site. Recently, the potential use of a new formulation of BMA, named BMA clot, has been preclinically described. In this report, we present the results of a prospective pilot clinical study aimed at evaluating the safety and efficacy of autologous vertebral BMA (vBMA) clot as a three-dimensional and multifunctional bioscaffold in instrumented posterior lumbar fusion.

METHODS: Ten consecutive patients with an indication of multilevel (≤5) posterior spinal fusion due to lumbar spine degenerative diseases were included in the study and treated with vBMA. Clinical outcomes were assessed using the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and EuroQoL-5L (EQ-5L) preoperatively and at 3 months and 12 months after spinal fusion. Bone fusion quality was evaluated at the 12-month follow-up using the Brantigan classification on radiography (XR) imaging. Bone density was measured on computed tomography (CT) scans at 6 and 12 months of follow-up visits at the intervertebral arches and intervertebral joint areas and expressed in Hounsfield unit (HU).

RESULTS: The results indicate a successful posterolateral fusion rate of approximately 100% (considering levels with C, D, and E grades according to the Brantigan classification) at the 12-month follow-up, along with an increase in bone density from 6 to 12 months of follow-up. An improvement in the quality of life and health status following surgery, as assessed by clinical scores (ODI, VAS, and EQ-5L), was also observed as early as 3 months postsurgery. No adverse events related to the vBMA clot were reported.

: This prospective pilot study demonstrates the effectiveness and safety profile of vBMA clot as an advanced bioscaffold capable of achieving posterior lumbar fusion in the treatment of degenerative spine diseases. This lays the groundwork for a larger randomized clinical study.

PMID:38260131 | PMC:PMC10801235 | DOI:10.3389/slot.2023.1245344

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Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study

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Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.ABSTRACTBACKGROUND: Bone marrow aspirate (BMA), when combined with graft substitutes, has long been introduced as a promising alternative to iliac crest bone graft in spinal fusion. However, the use of BMA is limited by the absence of a standardized procedure, a structural texture, and the potential
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