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Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review







Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review – PubMed









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Review

. 2021 Oct;30(10):2825-2838.


doi: 10.1007/s00586-021-06955-5.


Epub 2021 Aug 14.

Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review

Affiliations

Review

Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review

James Randolph Onggo et al.


Eur Spine J.


2021 Oct.


Abstract


Background:

Up to 70% of multiple myeloma (MM) patients develop vertebral metastasis and subsequent pathological vertebral fractures (PVF). With contemporary systemic therapies, life expectancy of MM patients has improved drastically, and the need to manage pain and associated disability from PVF is increasingly a high priority. The aim of this review is to provide an updated comprehensive synthesis of evidence in the use of vertebral augmentation, including percutaneous vertebroplasty (PV) and balloon kyphoplasty (BKP), to treat MM-related PVF.


Methods:

A comprehensive multi-database search in accordance with PRISMA guidelines was performed up to 10 February 2021. Relevant English language articles were selected and critically reviewed.


Findings:

A total of 23 clinical studies have been included in the review. PV and BKP showed significant pain and functional improvements in terms of analgesia requirements, Cervical Spine Function Score, Eastern Cooperative Oncology Group scale, EQ-5D score, Karnofsky score, Neck Pain Disability Index, Oswestry Disability Index, Short form-36 (SF-36) questionnaire and VAS pain scale. Both procedures also reported promising radiographic outcomes in terms of vertebral height improvement, maintenance and restoration, as well as kyphotic deformity correction. Asymptomatic cement leakage was commonly reported. There was no significant difference between the two procedures.


Conclusion:

PV and BKP are safe and effective procedure that offers pain relief, reduction in pain associated disability and reduction of fracture incidence. Its minimally invasive approach is associated with minimal morbidity risk, making it a viable option in frail patients.


Level of evidence iv:

Narrative review.


Keywords:

Augmentation; Balloon kyphoplasty; Cement; Myeloma; Spine; Vertebral augmentation; Vertebroplasty.

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References

    1. Amoretti N, Diego P, Amélie P, Andreani O, Foti P, Schmid-Antomarchi H et al (2018) Percutaneous vertebroplasty in tumoral spinal fractures with posterior vertebral wall involvement: feasibility and safety. Eur J Radiol 104:38–42



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    1. Anselmetti GC, Manca A, Montemurro F, Hirsch J, Chiara G, Grignani G et al (2012) Percutaneous vertebroplasty in multiple myeloma: prospective long-term follow-up in 106 consecutive patients. Cardiovasc Intervent Radiol 35(1):139–145



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    1. Audat ZA, Hajyousef MH, Fawareh MD, Alawneh KM, Odat MA, Barbarawi MM et al (2016) Comparison if the addition of multilevel vertebral augmentation to conventional therapy will improve the outcome of patients with multiple myeloma. Scoliosis Spinal Disord 11:47



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Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review

Role of vertebroplasty and balloon kyphoplasty in pathological fracture in myeloma: a narrative review

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