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Role of degenerated neuron density of dorsal root ganglion on anterior spinal artery vasospasm in subarachnoid hemorrhage: experimental study

BACKGROUND: The spinal arteries are innervated by several systems that contribute to the control of spinal cord blood flow. The sensory fibers of upper cervical nerves have vasodilatatory effect on the anterior spinal arteries (ASA). Subarachnoid hemorrhage (SAH) causes severe vasospasm by various neurochemical mechanisms. We examined whether there is a relationship between the neuron density of the C3 dorsal root ganglion and the severity of ASA vasospasm in SAH. METHODS: This study was conducted on 20 rabbits. Four of them were used as baseline group. Experimental SAH has been applied to all of 16 animals by injecting homologous blood into cisterna magna. After 20 days of injection, ASA and C3 dorsal root ganglia (C3DRG) were examined histopathologically. ASA volume values and normal and degenerated neuron densities of C3DRG were estimated stereologically and the results were analyzed statistically. RESULTS: The mean ASA volume was 1.050+/-0.450 mm(3), [corrected] and the mean neuronal density of C3DRG was 10,500 +/- 850 in all animals. The mean volume value of ASA was 0.970+/-0.150 [corrected] mm(3), and the normal neuron density of C3DRG fell to 8,600 +/- 400/mm(3) in slight vasospasm group. In severe vasospasm-developed animals, mean volume value of ASA was 0.540+/-0.90 [corrected]mm(3) and the normal neuron density of C3DRG fell to 5,500 +/- 360/mm(3). An inverse relationship between the degenerated neuronal density of the C3DRG and ASA volume values may indicate the severity of ASA vasospasm. CONCLUSION: The neuron density of C3DRG may be an important factor on the regulation of ASA volume values and the continuation of spinal cord blood flow. Low neuron density of C3DRG may be considered as an important factor in the pathogenesis of severe ASA vasospasm in SAH

Keywords : Animals,Anterior Spinal Artery Syndrome,Arteries,blood,blood supply,Cell Count,complications,Disease Models,Animal,Disease Progression,etiology,Ganglia,Spinal,Hemorrhage,Male,methods,Nerve Degeneration,Neurosurgery,pathology,physiopathology,Rabbits,Sensory Receptor Cells,Spinal Cord,Subarachnoid Hemorrhage,Turkey,Universities,Vasospasm,Intracranial,, Degenerated,Neuron,Density, fibromyalgia specialist uk

Date of Publication : 2010 Dec

Authors : Kanat A;Yilmaz A;Aydin MD;Musluman M;Altas S;Gursan N;

Organisation : Department of Neurosurgery, Rize University, Turkey. [email protected]

Journal of Publication : Acta Neurochir (Wien )

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/20835838

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I have known Dr Akmal and his team for the past 8 years, I have seen him and his team ON and OFF for issues regarding my neck, C4/5, C5/6 , C6/7. I first had 3 lots of injections into this area back at the start of things. This helped me for 3 years. Dr Akmal did not want to operate at the time due to my age still been under 40 then. After 3 years I had to see Dr Akmal and his team again. We tried the injection route again but after a few attempts we then had to make the call to cut. I had C5/6 and C6/7 +/- C4/5 anterior cervical decompression and fusion / disc replacement carried out. This was a success and I was out of the hospital within 3 days and recovery took place for the next few months. This year I was operated on the back of my neck for a posterior cervical foraminotomy on the left side at the C5/6 and C6/7 levels. We tried the injections last year but this did not help. Due to Covid to this should have been carried out last year. Dr Akmal explained the risks include nerve injury, dural tear and pain post-operatively but the procedure is fairly routine and the risks are relatively low. Surgery has now taken place back in February. I was released the same day later that evening and been back for my check ups and things are looking up. I am currently training for a half triathlon that I will take part in second week of July. I am doing anything from 120 km to 170 km a week on the bike and running now upto 10 km a day on my running days. I have not been able to swim yet due to pools been closed but I have no issues with movement in me neck. I am very happy I chose Dr Akmal from the start. I did seen two others before him, they were happy to just cut and not look at what was best for me. I also strongly believe the newer technology Dr Akmal uses has really helped me any my life style I lead with sports. I know I would not have had the same results if I did not take the route with Dr Akmal. I really can’t say much more but I am very happy I met Dr Akmal when I did, he has been great and so has his team. Patient Miles McWilliams 😊
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