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Rituximab Restores IFN-?-STAT1 Operate and Ameliorates Disseminated Mycobacterium avium An infection in a Affected person with Anti-Interferon-? Autoantibody.
J Clin Immunol. 2017 Oct;37(7):644-649
Authors: Koizumi Y, Sakagami T, Nishiyama N, Hirai J, Hayashi Y, Asai N, Yamagishi Y, Kato H, Hagihara M, Sakanashi D, Suematsu H, Ogawa Okay, Mikamo H
Summary
A 67-year-old Japanese feminine with again ache and extreme cachexia visited our hospital. The analysis was disseminated Mycobacterium avium complicated an infection (dMAC) with a number of bone involvement. Anti-mycobacterial chemotherapy was began, however fever continued and dislocation of cervical vertebrae has made her bedridden. As a result of anti-interferon (IFN)-? autoantibody was optimistic, 4 doses of rituximab 375 mg/m2, each 7 day, had been administered. Quickly after remedy, development of osteolytic lesions and losing has stopped. We proved that rituximab has recovered IFN-? signaling as proven by IFN-?-induced STAT1 phosphorylation. It may be a promising possibility for dMAC circumstances with anti-IFN-? autoantibody.
PMID: 28779413 [PubMed – indexed for MEDLINE]