Uncommon Thymoma Metastases to the Backbone: Case Studies and Evaluation of the Literature.
World Neurosurg. 2018 Feb;110:423-431
Authors: Achey RL, Lee BS, Sundar S, Benzel EC, Krishnaney AA
BACKGROUND: We report a sequence of three instances of metastatic thymoma to the backbone with spinal wire compression. An intensive literature overview of thymic metastases to the backbone was accomplished to offer a complete appraisal of present prognostic indicators and potential remedy algorithms to assist information clinicians in remedy administration.
CASE DESCRIPTIONS: Between 2000 and 2017, three sufferers acquired diagnoses of thymic metastases to the backbone at our establishment. Metastasis presentation occurred from 2 to eight years after the preliminary analysis with thymic most cancers. All three sufferers introduced with indicators and signs of spinal wire/cauda equina compression, and underwent surgical intervention. Postoperative therapies various amongst all three sufferers, 1 receiving chemotherapy, one other present process radiation, and the third having had no additional remedy due to in depth systemic illness.
CONCLUSIONS: Upon overview of the literature, 16 case experiences/sequence described 28 whole sufferers with backbone metastases secondary to thymoma/thymic carcinoma. The displays various extensively, together with age, neurologic deficits, time from preliminary analysis to metastasis, and histologic grading. The one extensively accepted prognostic issue is completeness of tumor resection, whereas medical staging, histologic kind, or each can also have prognostic worth. Thus, gross whole resection and spinal decompression ought to be prioritized in instances of surgical intervention. Chemotherapy and radiotherapy are usually really useful. Nevertheless, given the dearth of standardized remedy algorithms, individualized regimens ought to be formulated on a case-specific foundation.
PMID: 29223525 [PubMed – indexed for MEDLINE]