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Psoriasis, fracture threat and bone mineral density: the HUNT Examine, Norway.

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Psoriasis, fracture threat and bone mineral density: the HUNT Examine, Norway.

Br J Dermatol. 2017 Might;176(5):1162-1169

Authors: Modalsli EH, Åsvold BO, Romundstad PR, Langhammer A, Hoff M, Forsmo S, Naldi L, Saunes M

BACKGROUND: An affiliation between psoriasis and osteoporosis has been reported.
OBJECTIVES: To research, in a big potential population-based Norwegian research, whether or not psoriasis is related to elevated threat of forearm or hip fracture; to analyze the cross-sectional affiliation between psoriasis and bone mineral density (BMD) T-score in a subpopulation.
METHODS: Hospital-derived fracture information from Nord-Trøndelag County (1995-2013) have been linked to psoriasis data, BMD measurements and life-style components from the third survey of the Nord-Trøndelag Well being Examine 2006-08 (HUNT3); socioeconomic information from the Nationwide Training Database; and use of remedy from the Norwegian Prescription Database.
RESULTS: Amongst 48 194 contributors in HUNT3, we discovered no elevated threat of forearm or hip fracture in 2804 sufferers with self-reported psoriasis [overall age- and sex-adjusted hazard ratio 1·03, 95% confidence interval (CI) 0·82-1·31]. No clear affiliation was discovered between psoriasis and imply BMD T-score; general age- and sex-adjusted variations in whole hip, femoral neck and lumbar backbone BMD T-scores have been Zero·02 (95% CI -Zero·11 to Zero·14), Zero·05 (95% CI -Zero·06 to Zero·17) and Zero·07 (95% CI -Zero·09 to Zero·24), respectively. No clear affiliation was discovered between psoriasis and prevalent osteoporosis in both whole hip, femoral neck or lumbar backbone; general age- and sex-adjusted odds ratio was Zero·77 (95% CI Zero·54-1·10). Associations didn’t change considerably after adjustment for schooling, smoking, systemic steroid use and physique mass index.
CONCLUSIONS: We discovered no affiliation between psoriasis and threat of fracture. The research didn’t point out diminished BMD T-score or increased prevalence of osteoporosis amongst sufferers with psoriasis.

PMID: 27718508 [PubMed – indexed for MEDLINE]

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