Prognostic Elements in Surgical Sufferers with Chordomas of the Cervical Backbone: A Examine of 52 Circumstances from a Single Establishment.
Ann Surg Oncol. 2017 Aug;24(eight):2355-2362
Authors: Zhou H, Jiang L, Wei F, Joeris A, Hurtado-Chong A, Kalampoki V, Rometsch E, Yu M, Wu F, Dang L, Liu X, Liu Z
BACKGROUND: The recurrence price of cervical chordomas is excessive, and therefore you will need to discern the prognostic components for native relapse and general survival (OS).
METHODS: A retrospective overview of 52 sufferers with cervical chordoma operated in our establishment from January 1999 to March 2015 was carried out. The affiliation of clinicopathologic traits with native relapse-free survival (LRFS) and OS was analyzed. Univariate evaluation was carried out to find out whether or not tumor traits and varieties of remedy affected prognosis, and a multivariate Cox proportional hazard mannequin was developed to additional examine native recurrence and mortality.
RESULTS: Imply follow-up time was 50 months. The cumulative 5- and 10-year LRFS was 35 and zero%, respectively, whereas the cumulative 5- and 10-year OS was 69 and 53%, respectively. The univariate evaluation recognized contiguous segments concerned, intralesional surgical margin at major surgical procedure, major surgical procedure in native hospital, incisional biopsy, and with out adjuvant radiotherapy as unfavourable prognostic components for LRFS, whereas for OS, solely tumor location within the higher cervical backbone was statistically important. Within the multivariate evaluation, contiguous vertebral segments concerned, intralesional surgical margins, and incisional biopsy had been recognized as unfavourable prognostic components for LRFS, whereas for OS, once more solely tumor location within the higher cervical backbone was statistically important.
CONCLUSIONS: Contiguous vertebral segments concerned, intralesional surgical margin, with out adjuvant radiotherapy, and incisional biopsy considerably enhance native recurrence, whereas tumor location within the higher cervical backbone considerably will increase tumor-related mortality. Thus, computed tomography-guided fine-needle aspiration biopsy and complete spondylectomy with marginal excision might enhance survival of sufferers with cervical chordoma.
PMID: 28593502 [PubMed – indexed for MEDLINE]