Main spinal mucosa-associated lymphoid tissue lymphoma: A case report.
Medication (Baltimore). 2018 Jan;97(four):e9329
Authors: Dong R, Ji J, Liu H, Wang J, He X
RATIONALE: Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent B-cell lymphoma which happens primarily within the organs having mucosal layer and owns a reasonably good prognosis. To this point, 7 instances of spinal major MALT has been reported earlier than. Nonetheless, there is no such thing as a consensus on the optimum adjuvant remedy modalities for major spinal MALT. The goal of this research was so as to add a brand new case of MALT which responded nicely to systemic remedy to the literature and to evaluate the present literature.
PATIENT CONCERNS: A 68-year-old lady visited to our hospital on account of again ache and progressive bilateral decrease extremity weak point for two months. Magnetic resonance imaging (MRI) of the backbone revealed a diffusely contrast-enhancing epidural mass extending from vertebral physique T6 to T8 with compression of the spinal twine. Because of the spinal twine compression, affected person underwent surgical resection. Histological examination indicated monocytoid small B-cells. Immunochemical research demonstrates that the majority tumor cells have been constructive for CD20, CD21, CD45, CD79a, CD43, bcl-2 with Ki-67 labing index was 15%, however have been damaging for CD3, CD5 cyclin D1, BCL6, and CD23. The positron emission tomography/laptop tomography (PET/CT) revealed that proper iliac wing and proper liver have been metastases for the usual uptake worth (SUV) have been 9.05 and eight.35, respectively.
DIAGNOSES: Based mostly on these findings, ultimate prognosis of spinal MALT lymphoma was made.
INTERVENTIONS: After the prognosis, the affected person obtained 6 cycles of immuno-chemotherapy and repeated intrathecal methotrexate and intrathecal cytarabine.
OUTCOMES: At 1 yr observe up, no recurrence or different dissemination was detected.
LESSONS: Chemotherapy and/or radiation have been employed in bigger case sequence. Whereas there is no such thing as a outlined remedy guideline for this uncommon illness entity, our reported case suggests a positive prognosis when combining each surgical and adjuvant systemic method.
PMID: 29369169 [PubMed – in process]