Major spinal twine astroblastoma: case report.
J Neurosurg Backbone. 2018 Mar 02;:1-5
Authors: Yamada SM, Tomita Y, Shibui S, Takahashi M, Kawamoto M, Nobusawa S, Hirato J
Astroblastoma is a uncommon tumor that’s thought to happen solely within the cerebrum. To the authors’ information, no circumstances of spinal twine astroblastoma have been reported. A 20-year-old girl introduced with numbness in her legs. MRI demonstrated a 2-cm intramedullary enhancing lesion within the spinal twine on the T-1 degree. The affected person declined to endure resection of the tumor as a result of she was in a position to stroll unassisted; nevertheless, she returned for surgical procedure 1 month later as a result of she had developed paraplegia with bladder and rectal dysfunction, and MRI confirmed enlargement of the tumor. Intraoperatively, the border between the tumor and regular tissue was poorly outlined. Biopsy samples have been obtained for histopathological examinations, and a prognosis of astroblastoma with a Ki-67 index of 5% was made. Contemplating the speedy tumor progress on MRI and noteworthy deterioration in her signs, the affected person was handled with a mixture of radiation remedy, temozolomide (TMZ), and bevacizumab. After completion of the mixed therapy, she was in a position to transfer her toes, and oral TMZ and bevacizumab injections have been continued. Six months later, particular tumor shrinkage was recognized on MRI, and the affected person was in a position to get up from a wheelchair with out help and stroll by herself. No therapeutic regimens for residual astroblastoma are established; nevertheless, on this case the authors’ therapeutic technique was profitable in treating the spinal twine astroblastoma.
PMID: 29498581 [PubMed – as supplied by publisher]