Major Extradural Melanoma Arising in Cervical Spinal Nerve Root.
World Neurosurg. 2017 Dec 27;:
Authors: Zou C, Cheng W, Zhu C, Guo Q, Wu A
BACKGROUND: Major cervical melanoma is uncommon; that is very true of extradural melanoma arising within the nerve root. Characterizing these circumstances can present a foundation for improved melanoma administration.
CASE DESCRIPTION: A 42-year-old feminine affected person with numbness and ache in the suitable shoulder and arm persisting for five years was admitted. Preoperative magnetic resonance imaging revealed an epidural ladle-shaped mass form past the C7-T1 intervertebral foramen that resembleda nerve sheath tumor. Histopathologic evaluation following full resection confirmed the lesion as malignant melanoma. Radiotherapy and temozolomide and cisplatin chemotherapy had been administered in an accompanying hospital with common follow-ups atour establishment. After 2 months of postoperative adjuvant remedy, hepatic metastatic lesions developed. The chemotherapy routine was modified to carboplatin, nab-paclitaxel, and recombinant human endostatin injections for a 6-month interval. A follow-up 8months after chemotherapy (16 months post-surgery) indicated an excellent prognosis.
CONCLUSIONS: Previously 10 years just one case of major extradural spinal melanoma incervical intervertebral foramen has been described, with no reported circumstances of hepatic metastasis. As radiographic outcomes should not unequivocal, a prognosis of spinal melanoma should be primarily based on post-operative histological affirmation. Nevertheless, up to now there isn’t any customary post-operative adjuvant remedy for these sufferers. The chemotherapy routine described on this report has broader implications for melanoma remedy.
PMID: 29288844 [PubMed – as supplied by publisher]