Prevalence and danger components of low bone mineral density in spondyloarthritis and prevalence of vertebral fractures.
BMC Musculoskelet Disord. 2017 Aug 22;18(1):357
Authors: Malochet-Guinamand S, Pereira B, Tatar Z, Tournadre A, Moltó A, Dougados M, Soubrier M
BACKGROUND: Examine the prevalence and danger components of low bone mineral density (BMD) in sufferers with axial spondyloarthritis in addition to investigating the prevalence of vertebral fractures.
METHODS: Sufferers underwent BMD measurements with dual-energy X-ray absorptiometry (DXA) within the anterior-posterior lumbar backbone, lateral backbone and hip. We screened for vertebral fractures utilizing vertebral fracture evaluation, after which checked for syndesmophytes on the VFA pictures. Sociodemographic and scientific variables have been collected.
RESULTS: A complete of 89 sufferers (41,6% feminine) took half within the research with a imply age of 44 ± 14 years and illness length 10.2 ± 10.6 years. In line with World Well being Group (WHO) standards, 48,three% of sufferers displayed osteopenia and 6,7% osteoporosis. Within the subgroup of ladies who underwent measurement in any respect websites together with the lateral backbone, the prevalence of osteopenia was 39.three% within the anterior-posterior backbone, 32.1% within the lateral backbone, and 64.three% with all websites collectively. VFA led to the analysis of not less than one vertebral fracture in 6.2% of sufferers. On VFA, syndesmophytes have been present in 24.three% of sufferers. The variables related in multivariate analyses with low BMD in numerous measurement websites have been low physique mass index (BMI), a excessive doctor’s international evaluation rating, a excessive Bathtub Ankylosing Spondylitis Useful Index (BASFI) rating and feminine gender.
CONCLUSION: Our research discovered a excessive prevalence (round 50%) of low BMD in SpA. Conversely, the prevalence of osteoporosis (6.7% in accordance with WHO standards) and vertebral fractures (6.2%) was decrease than usually reported within the literature. Whereas lateral backbone BMD measurement did little to enhance the detection of osteopenia in girls, the pattern measurement was not giant sufficient to allow us to attract particular conclusions.
PMID: 28830392 [PubMed – indexed for MEDLINE]