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Preoperative quality of life in patients with degenerative spinal disorders: many are worse than patients with brain tumours and cancer

BACKGROUND: This study compared prospectively the quality of life (QoL), function and mood of patients about to undergo surgery for either an intracranial supratentorial tumour or a spinal degenerative condition. The QoL scores were also compared to that of cohorts with a range of extracranial cancers. MATERIAL AND METHODS: The study took place in a Scottish NHS Neurosurgical Unit. Patients were assessed on the day prior to surgery for their QoL (European Organisation for Research and Treatment of Cancer (EORTC)-QLQ C30), mood status (Hospital Anxiety and Depression Score), Performance status (Karnosky Score, timed 10-m walk) and disability (Barthel Disability Index). All tests were performed by a single trained psychologist. RESULTS: Between 2007 and 2009, 101 patients with intracranial tumours, 75 age- and gender-matched patients with degenerative spinal disorders and 80 healthy adults were evaluated. There was no difference in the mood or disability scores between the two patient cohorts, but mood was significantly worse than a matched healthy cohort. The spinal cohort had significantly worse scores on the Karnovsky Scale, timed 10-m walk and for Global Health than those of the brain tumour cohort. They also had worse mean scores on all five functional scales, as well as six of the nine symptom/single-item scales, of the EORTC QLQ C30. SUMMARY: Patients with degenerative spinal disorders awaiting surgery on the NHS have significantly impaired QoL in multiple domains as well as other functional and mood disorders. Not only are their scores worse than a brain tumour cohort but they are also worse than many cancer cohorts described in the literature using the EORTC QLQ C30. These findings suggest that preoperative care, assessment and management of NHS patients with degenerative spinal disorders could be improved and that the EORTC QLQ C30 may be a useful tool for audit purposes in this cohort

Keywords : Adult,Affect,Anxiety,Brain,Brain Neoplasms,Case-Control Studies,Depression,Female,Glioma,Humans,Karnofsky Performance Status,Male,methods,Middle Aged,Neurodegenerative Diseases,Patients,Preoperative Care,Prospective Studies,psychology,Quality of Life,surgery,Time-to-Treatment,Universities,, Quality,Life, fibromyalgia private treatment

Date of Publication : 2012 Aug

Authors : Whittle IR;Scotland J;Dengu F;Anpalakhan S;Deary IJ;

Organisation : Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK. ian.whittle@ed.ac.uk

Journal of Publication : Br J Neurosurg

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/22208612

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