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Porosity of beta-tricalcium phosphate affects the results of lumbar posterolateral fusion

STUDY DESIGN: Clinical case-control and cross-sectional study. OBJECTIVES: To determine the influence of different porosities of beta-tricalcium phosphate (beta-TCP) as a bone substitute combined with local autograft bone obtained from decompression for lumbar posterolateral fusion (PLF). SUMMARY OF BACKGROUND DATA: Several reports have documented a high bone fusion rate using beta-TCP as a bone substitute. beta-TCP is increasingly used to supplement autograft in lumbar PLF, but the influence of different porosities of beta-TCP for the lumbar PLF has not been reported. METHODS: Sixty patients who were diagnosed with lumbar degenerative diseases and treated with 2-level noninstrumented lumbar PLF were divided into 2 groups. Thirty patients were treated with 75% porous beta-TCP (beta-TCP-75 group), and the others were treated with 60% porous beta-TCP (beta-TCP-60 group). The clinical and radiographic results of each patient were assessed at 2 years postoperatively. RESULTS: Both the groups showed a good improvement rate of the Japanese Orthopaedic Association score (JOA score) at 2 years postoperatively, but there were no significant differences between them. The beta-TCP-75 group represented a bone fusion rate of 70.0% (64.7% in men, 76.9% in women) and the beta-TCP-60 group was 93.3% (87.5% in men, 100.0% in women). The latter exhibited a significantly better bone fusion rate than the beta-TCP-75 group (P<0.05). CONCLUSIONS: In lumbar PLF, 60% porous beta-TCP granules achieved a higher bone fusion rate than 75% porous beta-TCP granules Keywords : administration & dosage,Affect,Aged,Aged,80 and over,Biocompatible Materials,Calcium,Calcium Phosphates,Case-Control Studies,chemistry,Cross-Sectional Studies,diagnostic imaging,Female,Humans,Japan,Lumbar Vertebrae,Male,methods,Middle Aged,Patients,Porosity,Radiography,Spinal Diseases,Spinal Fusion,surgery,Treatment Outcome,Universities,, ?Tricalcium,Phosphate,Affects, pain clinics near me

Date of Publication : 2013 Apr

Authors : Wang Z;Sakakibara T;Sudo A;Kasai Y;

Organisation : Departments of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan

Journal of Publication : J Spinal Disord Tech

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/22124423

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