19 Harley St, London, W1G 9QJ, UK

Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline

PURPOSE: To present guidance for patients and physicians regarding the use of radiotherapy in the treatment of bone metastases according to current published evidence and complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the National Library of Medicine’s PubMed database between 1998 and 2009 yielded 4,287 candidate original research articles potentially applicable to radiotherapy for bone metastases. A Task Force composed of all authors synthesized the published evidence and reached a consensus regarding the recommendations contained herein. RESULTS: The Task Force concluded that external beam radiotherapy continues to be the mainstay for the treatment of pain and/or prevention of the morbidity caused by bone metastases. Various fractionation schedules can provide significant palliation of symptoms and/or prevent the morbidity of bone metastases. The evidence for the safety and efficacy of repeat treatment to previously irradiated areas of peripheral bone metastases for pain was derived from both prospective studies and retrospective data, and it can be safe and effective. The use of stereotactic body radiotherapy holds theoretical promise in the treatment of new or recurrent spine lesions, although the Task Force recommended that its use be limited to highly selected patients and preferably within a prospective trial. Surgical decompression and postoperative radiotherapy is recommended for spinal cord compression or spinal instability in highly selected patients with sufficient performance status and life expectancy. The use of bisphosphonates, radionuclides, vertebroplasty, and kyphoplasty for the treatment or prevention of cancer-related symptoms does not obviate the need for external beam radiotherapy in appropriate patients. CONCLUSIONS: Radiotherapy is a successful and time efficient method by which to palliate pain and/or prevent the morbidity of bone metastases. This Guideline reviews the available data to define its proper use and provide consensus views concerning contemporary controversies or unanswered questions that warrant prospective trial evaluation

Keywords : Bone Diseases,Bone Neoplasms,Humans,Kyphoplasty,methods,Morbidity,Pain,Patients,Physicians,Prospective Studies,Radiosurgery,radiotherapy,Safety,secondary,Societies,Medical,Spinal Cord,Spinal Cord Compression,Spine,surgery,Time,United States,Vertebroplasty,, Radiotherapy,Bone,Metastases, how long does piriformis syndrome last

Date of Publication : 2011 Mar 15

Authors : Lutz S;Berk L;Chang E;Chow E;Hahn C;Hoskin P;Howell D;Konski A;Kachnic L;Lo S;Sahgal A;Silverman L;von GC;Mendel E;Vassil A;Bruner DW;Hartsell W;

Organisation : Department of Radiation Oncology, Blanchard Valley Regional Cancer Center, Findlay, OH 45840, USA. slutz@bvha.org

Journal of Publication : Int J Radiat Oncol Biol Phys

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21277118

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Palliative radiotherapy for bone metastases an ASTRO evidence-based guideline | Microdiscectomy for sciatica recovery time

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810