P2X7 receptor in spinal tuberculosis: Gene polymorphisms and protein ranges in Chinese language Han inhabitants.
Infect Genet Evol. 2018 Jan;57:138-144
Authors: Zhou Y, Tan CY, Mo ZJ, Gao QL, He D, Li J, Huang RF, Li YB, Guo CF, Guo Q, Wang LJ, Yang GT, Zhang HQ
Spinal tuberculosis (TB) accounts for 1%-5% of all TB infections. Host genetic variation influences susceptibility to Mycobacterium tuberculosis (MTB). P2X7 receptor (P2X7R) expressed on cells has been recognized as a regulatory molecule in cell demise/apoptosis, killing of intercellular pathogens, and bone turnover. This research investigated the P2X7 gene polymorphisms and protein ranges in spinal TB. P2X7 gene -762C>T and 489C>T polymorphisms had been genotyped. The expression of P2X7R in bone or intervertebral disc (ID) tissues was analyzed by Western blot assay. The -762C>T and 489C>T polymorphisms had been related to susceptibility to spinal TB. Having the -762CC genotype and -762C allele elevated the chance of creating spinal TB (CC vs. TT: P=zero.031, OR [95%CI]=1.865 [1.053-3.304]; C vs. T: P=zero.028, OR [95%CI]=1.355 [1.034-1.775]). The presence of the 489T allele was related to an elevated danger of creating spinal TB (TT vs. CC: P=zero.004, OR [95%CI]=2.248 [1.283-3.939]; CT vs. CC: P=zero.044, OR [95%CI]=1.755 [1.011-3.047]; T vs. C: P=zero.004, OR [95%CI]=1.482 [1.134-1.936]; TT+CT vs. CC: P=zero.010, OR [95%CI]=1.967 [1.171-3.304]; TT vs. CT+CC: P=zero.037, OR [95%CI]=1.489 [1.023-2.167]). The expression of P2X7R in TB-induced bone lesions elevated considerably amongst spinal TB sufferers (t=zero.011). Carrying the P2X7 -762CC genotype and 489T allele is related to an elevated danger of creating spinal TB in a Southern Chinese language Han inhabitants.
PMID: 29158203 [PubMed – indexed for MEDLINE]