[Outcome and prognosis of spinal myeloma surgery].
Zhonghua Zhong Liu Za Zhi. 2018 Feb 23;40(2):141-146
Authors: Liu WF, Li B, Yang FJ, Hao L, Li Y, Niu XH
Goal: To guage the impression of surgical procedure in ache reduction, high quality of life, neurological perform, survival standing and prognosis of spinal myeloma sufferers. Strategies: Twenty spinal myeloma sufferers from January 1990 to June 2016 who underwent surgical procedure have been reviewed. Evaluate the preoperative and postoperative neurological perform and high quality of life, through visible analogue scale (VAS), Jap Cooperative Oncology Group (ECOG) rating and Frankel classification, survival charge based mostly follow-up have been statistical analyzed by Wilcoxon and Kaplan-Meier respectively, univariate and multivariate evaluation with Cox regression mannequin. Outcomes: There have been 12 males and eight females enrolled with common age of 53.three (vary from 31 to 75 years). Lesions location distribution: cervical backbone 1 case, 12 in thoracic backbone, 6 in lumbar and 1 in sacral tumor. The vast majority of symptom was ache in 20 instances and 5 instances had incomplete paraplegia with spinal twine compression. Single posterior strategy in 15 instances, single anterior in three instances, anterior and posterior mixed strategy in 2 instances. The typical operation time was 225 min, common blood loss was 2 320 ml. The sufferers with postoperative median VAS rating and ECOG rating have been 2.00 and 1 respectively, it’s considerably decreased (P<zero.001) in contrast with the preoperative rating (7.50 and three), the median Frankel classification was stage 5 in postoperative sufferers and elevated considerably (P<zero.001) than preoperative sufferers (stage four). One affected person had native recurrence, 2 sufferers had issues. The general 5 and 10 12 months survival charge was 61.7% and 42.three%, respectively. The three years survival charge between surgical procedure mix chemotherapy and with out chemotherapy group was 87.1% and 25.zero%, 5 years survival charge was 79.1% and zero respectively (P<zero.01). LDH, ALB and chemotherapy have been unbiased prognostic components of survival from Cox regression. The percentages ratio (OR) was 1.037 (P=zero.006), zero.746 (P=zero.009) and zero.077 (P=zero.zero12) respectively. Conclusion: Surgical technique is efficient to enhance high quality of life for spinal myeloma sufferers. Mix chemotherapy may enhance the survival.
PMID: 29502376 [PubMed – indexed for MEDLINE]