Osteopenia and the bodily perform in Japanese sufferers with schizophrenia.
Arch Osteoporos. 2017 Oct 27;12(1):93
Authors: Uchida S, Ichinose T, Iizuka Y, Okamura Ok, Shitara H, Yamazaki M, Takagishi Ok, Iizuka H
We evaluated the state of osteopenia and the bodily perform in 121 schizophrenic sufferers. These elements have been worse within the inpatient group than within the outpatient group. The age, intercourse, physique mass index (BMI), and bodily perform have been correlated to the state of osteopenia. Physicians ought to think about the chance of osteopenia in aged feminine psychiatric sufferers with low BMI.
PURPOSE: Details about the precise state of osteopenia in sufferers with schizophrenia is proscribed. Within the current research, we evaluated the elements associated to osteopenia and affected person’s bodily perform and in contrast these elements between inpatients and outpatients.
METHODS: A complete of 121 schizophrenic sufferers have been included within the current research. We divided the sufferers into two teams in accordance with the therapeutic kind. We collected information on their age, intercourse, physique mass index (BMI), bone mineral density (BMD) within the lumbar backbone and proximal femur, serum bone metabolic markers, threat of fracture, and bodily perform.
RESULTS: The variety of fractured vertebrae, threat of fracture, serum focus of tartrate-resistant acid phosphatase 5b (TRACP-5b), and rating of locomo25 have been considerably increased and the BMI and BMD within the lumbar backbone and proximal femur considerably decrease within the inpatient group than within the outpatient group. A a number of regression evaluation confirmed that the age, intercourse, BMI, the variety of fractured vertebrae, and rating of locomo 25 have been correlated with the BMD within the lumbar backbone and proximal femur. Neither the therapeutic kind nor any bone metabolic markers have been correlated with the BMD. The inpatient group had a decrease common BMI, BMD, and bodily perform than the outpatient group. Nevertheless, a a number of regression evaluation confirmed that the therapeutic kind was not correlated with the BMD.
CONCLUSION: These findings recommend that physicians ought to think about aged feminine schizophrenic sufferers with a low BMI to be liable to creating osteopenia.
PMID: 29079989 [PubMed – indexed for MEDLINE]