Osteointegration and Resorption of Intravertebral and Extravertebral Calcium Phosphate Cement.
Clin Backbone Surg. 2017 Apr;30(three):E291-E296
Authors: Klein R, Tetzlaff R, Weiss C, Schäfer MK, Tanner M, Wiedenhöfer B, Grafe I, Meeder PJ, Noeldge G, Nawroth PP, Kasperk C
STUDY DESIGN: Eleven sufferers with painful osteoporotic vertebral fractures who underwent kyphoplasty utilizing calcium phosphate (CaP) cement have been adopted up for 1 week, 1, 2, and three years in a monocentric, nonrandomized, noncontrolled retrospective trial.
OBJECTIVE: This research investigates long-term radiomorphologic options of intraosseous CaP cement implants and of extraosseous CaP cement leakages for as much as three years after implantation by kyphoplasty.
SUMMARY OF BACKGROUND DATA: Kyphoplasty is incessantly used for the therapy of painful osteoporotic fractures. Of the supplies out there, CaP is incessantly used as a filling materials. Resorption of this materials is incessantly noticed, though medical final result is comparable with different cements.
METHODS: Kyphoplasty using CaP cement was carried out in 11 sufferers with painful osteoporotic vertebral fractures. All sufferers obtained a pharmacological antiosteoporosis therapy consisting of calcium, vitamin D, and a typical dose of oral bisphosphonates. Radiomorphologic measurements, ache, and mobility have been assessed.
RESULTS: Intraosseous and extraosseous CaP cement volumes decreased considerably over three years. Nonetheless, vertebral stability as decided by a relentless vertebral physique top and the sagittal index was not impaired. Ache improved considerably 2 years after implantation and the mobility scores 1 12 months after kyphoplasty not less than till the third 12 months.
CONCLUSIONS: Intravertebral CaP cement implants are resorbed slowly over time with out jeopardizing stability and medical outcomes almost definitely due to a slowly progressing osseous substitute. Extraosseous CaP cement materials due to leakages throughout the kyphoplasty process is nearly fully resorbed as early as 2 years after the leakage occurred. Subsequently, CaP cement is a vital different to PMMA-based cement supplies utilized for kyphoplasty of osteoporotic vertebral fractures.
PMID: 28323714 [PubMed – indexed for MEDLINE]