Optimizing bone cement stiffness for vertebroplasty by way of biomechanical results evaluation based mostly on patient-specific three-dimensional finite aspect modeling.
Med Biol Eng Comput. 2018 Could 28;:
Authors: Peng Y, Du X, Huang L, Li J, Zhan R, Wang W, Xu B, Wu S, Peng C, Chen S
Vertebroplasty is a standard and efficient therapy for symptomatic osteoporotic vertebral compression fractures. Nonetheless, the cemented and adjoining vertebras have a danger of recollapse on account of largely unassured mechanisms, amongst which extreme stiffness of bone cement could also be an vital danger issue. This research aimed to search out probably the most acceptable vary of bone cement stiffness by analyzing its biomechanical results on the augmented and adjoining vertebras of particular person affected person after vertebroplasty. A 3-dimensional finite aspect mannequin of T11-L1 osteoligamentous vertebras was reconstructed based on particular person computed tomography information and validated by put up mortem human topic experiment in literatures. Bone cement of various stiffness was injected into the trabecular core of the T12 vertebra simulatively. The utmost von Mises stresses on cancellous and cortical bones of T11-L1 vertebras had been analyzed below the loading situations of flexion, extension, bending, and torsion. For the adjoining T11 and L1 vertebras, the stepwise elevation of the bone cement elastic modulus elevated the utmost von Mises stress on the cancellous bone, however its impact on cortical bone was negligible. For the augmented T12 vertebra, the stresses on cancellous bone elevated just below the loading situation of lateral bending and remained no impression on cortical bone. The linear interpolation revealed that probably the most appropriate vary of cement elastic modulus is 833.1 and 1408.1 Mpa for this affected person. Elevated elastic modulus of bone cement might result in a rising danger of recollapse for the cemented vertebra in addition to the adjoining vertebras. Our research offers a contemporary perspective in scientific optimization of particular person remedy in vertebroplasty. Graphical summary ?.
PMID: 29806053 [PubMed – as supplied by publisher]