Live Video Consultation
19 Harley St, London, W1G 9QJ, UK

[Neuronal glycolipids regulate glial cell division negatively during development and following a lesion].

Related Articles

[Neuronal glycolipids regulate glial cell division negatively during development and following a lesion].

Rev Neurol. 2017 Jun 16;64(12):549-567

Authors: Nieto-Sampedro M, Muneton-Gomez VC

Summary
Glial cells within the central nervous system of grownup mammals outnumber neurons 10-fold. Their quantity stays stationary all through maturity, managed by the concomitant presence of mitogens and mitogen inhibitors. Essentially the most ample inhibitor, neurostatin, is ganglioside GD1b O-acetylated on hydroxyl 9 of its outermost sialic acid. Neurostatin inhibited the proliferation of major microglia and astroblasts in tradition (cytostatic) in addition to each rodent and human glioma cells (cytotoxic) at nanomolar concentrations. At these concentrations neurostatin had no impact on non-glial lineage cells or differentiated glia. Neurostatin exhibits direct antimitotic exercise on tumoral cells, interfering with a number of indicators regulating cell cycle development. Nevertheless it additionally promotes not directly complete destruction of experimental rat mind glioma, presumably by making it seen to the host immune system and activating CD4+ and CD8+ lymphocytes. Neurostatin could possibly be a brand new anti-inflammatory agent, with a number of convergent direct and oblique actions on glioma development, a pathology with out passable medical therapy. Neurostatin is produced by neurons however its expression is up-regulated by neuron-astrocyte contact. The motion of neurostatin could possibly be mediated by plenty of receptor proteins, together with integrins, Toll-like receptors and siglecs.

PMID: 28608355 [PubMed – indexed for MEDLINE]

Neuronal glycolipids regulate glial cell division negatively during development and following a lesion | London pain clinic harley street

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810