Neurologic late results related to radiologic proof of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome related to survivors of laryngeal and hypopharyngeal most cancers.
Head Neck. 2016 Aug;38(eight):1187-93
Authors: Rosko AJ, Spector ME, Griffin GR, Vainshtein JM, Lee J, Bradford CR, Prince ME, Moyer JS, Worden FP, Eisbruch A, Chepeha DB
BACKGROUND: Delayed nonspecific posterior neck ache after pharyngeal instrumentation could be related to a syndrome of quickly progressive neurologic embarrassment. We current this cohort to assist outline the syndrome and assist in early detection.
METHODS: We carried out a retrospective case collection of 6 sufferers presenting from 2003 to 2012 with a historical past of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) adopted by salvage laryngectomy.
RESULTS: Posterior neck and higher again ache developed a imply of 27.5 days after instrumentation of the pharynx (reconstruction after laryngectomy or pharyngeal dilation). Myelopathy developed a median of 21.5 days after the onset of posterior neck ache. 5 sufferers required pressing decompression. Three sufferers developed quadriplegia. The disease-specific mortality was 50%.
CONCLUSION: There’s a syndrome of late neurological results after RT, salvage surgical procedure, and pharyngeal instrumentation that’s related to excessive morbidity and mortality. © 2016 Wiley Periodicals, Inc. Head Neck 38:1187-1193, 2016.
PMID: 27080049 [PubMed – indexed for MEDLINE]