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Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion – Lumbar Fusion

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This article is a retrospective cohort study that investigates the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF). The study finds that patients with DISH have a higher risk of pseudoarthrosis, or failed bone fusion, after TLIF compared to those without DISH. The risk is particularly higher for patients with DISH whose caudal end is below Th11. This study highlights the importance of considering DISH as a risk factor when assessing outcomes of TLIF procedures. PMID: 37788972 | DOI: 10.31616/asj.2022.0453

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most specialised spine hospital in the world

Published article

S: DISH is an independent risk factor for pseudoarthrosis after one intervertebral TLIF, and DISH with a caudal end below Th11 is associated with a higher risk of pseudoarthrosis than DISH without a caudal end below Th11.

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Asian Spine J. 2023 Oct 4. doi: 10.31616/asj.2022.0453. Online ahead of print.ABSTRACTSTUDY DESIGN: This study adopted a retrospective cohort study design.PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF).OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have,

Asian Spine J. 2023 Oct 4. doi: 10.31616/asj.2022.0453. Online ahead of print.

ABSTRACT

STUDY DESIGN: This study adopted a retrospective cohort study design.

PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF).

OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis. Patients with DISH have significantly more reoperations after posterior lumbar fusion, including TLIF. However, the effects of DISH on bone fusion after TLIF have not been reported.

METHODS: The medical records of patients with intervertebral TLIF from 2012 to 2018 were retrospectively examined. The patients were divided into those with fusion and those with pseudoarthrosis, and the following data were compared: age, sex, DISH, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m2, and L5/S fixation. Statistical analyses were performed using regression models.

RESULTS: In this study, 180 patients (78.6%) had fusion and 49 patients (21.4%) had pseudoarthrosis. The number of patients with DISH was significantly higher in the pseudoarthrosis group than in the fusion group (36.7% and 21.7%, respectively; univariate p=0.031, multivariate p =0.019). No significant differences in age, sex, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m2, and L5/S fixation were observed between the two groups. The risk factors for bone fusion were statistically analyzed in 57 patients with DISH. DISH with a caudal end below Th11 was an independent risk factor for pseudoarthrosis (univariate p=0.011, multivariate p=0.033).

S: DISH is an independent risk factor for pseudoarthrosis after one intervertebral TLIF, and DISH with a caudal end below Th11 is associated with a higher risk of pseudoarthrosis than DISH without a caudal end below Th11.

PMID:37788972 | DOI:10.31616/asj.2022.0453

The London Spine Unit : most specialised spine hospital in the world

Read the original publication:

Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion

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Asian Spine J. 2023 Oct 4. doi: 10.31616/asj.2022.0453. Online ahead of print.ABSTRACTSTUDY DESIGN: This study adopted a retrospective cohort study design.PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF).OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have

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