Multi-parameter analysis of lumbar intervertebral disc degeneration utilizing quantitative magnetic resonance imaging methods.
Am J Transl Res. 2018;10(2):444-454
Authors: Xiong X, Zhou Z, Figini M, Shangguan J, Zhang Z, Chen W
Goal: To quantitatively consider lumbar disc degeneration with recently-developed quantitative magnetic resonance imaging (MRI) methods. A sequence of MRI parameters, together with T2*, T1rho leisure time, obvious diffusion coefficient and gagCEST, have been in contrast and correlated with the Pfirrmann semi-quantitative classification of lumbar intervertebral disc degeneration; probably the most correct and related MRI parameters of lumbar disc degeneration have been recognized. Supplies and Strategies: Thirty-seven topics (age vary, 18-74 years) with non-specific low again ache (LBP) for greater than 6 months have been enrolled. The L1/2-L5/S1 discs of every topic have been measured after which analyzed. Outcomes: The gagCEST worth of the discs confirmed the perfect unfavourable correlation with degeneration degree (nucleus pulposus: r = -Zero.951, P < Zero.001; annulus fibrosus: r = -Zero.938, P < Zero.001). The discriminant evaluation outcomes confirmed that this parameter additionally had the best appropriate charge utilizing a single index (gagCEST discriminant accuracy = 82%). Conclusion: Early stage lumbar disc degeneration may be quantitatively evaluated with MRI utilizing the chemical change saturation switch method.
PMID: 29511438 [PubMed]