MRI-guided centered ultrasound ablation of lumbar medial department nerve: Feasibility and security examine in a swine mannequin.
Int J Hyperthermia. 2016 Nov;32(7):786-94
Authors: Kaye EA, Monette S, Srimathveeravalli G, Maybody M, Solomon SB, Gulati A
PURPOSE: About 10-40% of power low again ache instances contain aspect joints, that are generally handled with lumbar medial department (MB) radiofrequency neurotomy. Magnetic resonance imaging-guided centered ultrasound (MRgFUS), a non-invasive, non-ionising ablation modality used to deal with tumours, neuropathic ache and painful bone metastasis will also be used to disrupt nerve conduction. This work’s goal was to review the feasibility and security of direct MRgFUS ablation of the lumbar MB nerve in acute and subacute swine fashions.
MATERIALS AND METHODS: In vivo MRgFUS ablation was carried out in six swine (three acute and three subacute) utilizing a medical MRgFUS system and a Three-T MRI scanner mixture. Behavioural evaluation was carried out, and imaging and histology have been used to evaluate the therapy.
RESULTS AND CONCLUSIONS: Histological evaluation of the in vivo research confirmed thermal necrosis of the MB nerve could possibly be achieved with out damaging the spinal twine or adjoining nerve roots. MRgFUS didn’t trigger modifications within the animals’ behaviour or ambulation.
PMID: 27443328 [PubMed – indexed for MEDLINE]