Mortality following benign sacral insufficiency fracture and related danger elements.
Arch Osteoporos. 2017 Nov 09;12(1):100
Authors: Park JW, Park SM, Lee HJ, Lee CK, Chang BS, Kim H
This examine demonstrated elevated mortality following sacral insufficiency fractures as with different main osteoporotic fractures. The 6-month mortality charge was 9.eight%, the 1-year mortality charge was 17.5%, and the Three-year mortality charge was 25.5%. Intercourse- and age-adjusted standardized mortality ratio elevated after fractures.
INTRODUCTION: There are not any knowledge about mortality after sacral insufficiency fractures. The needs of this examine have been to research the mortality charge amongst sacral insufficiency fracture sufferers and to determine danger elements related to mortality.
METHODS: This can be a retrospective cohort examine of sufferers identified with sacral insufficiency fracture by way of radiological examination in a single institute from 2001 to 2014, excluding sufferers with pathological sacral fracture because of metastasis or main tumor. Mortality and its predisposing elements have been analyzed primarily based on a evaluation of digital medical information and mortality knowledge supplied by the Korean Statistical Data Service. Kaplan-Meier survival evaluation and Cox regression evaluation have been used for statistical evaluation.
RESULTS: A complete of 325 sufferers have been included (275 ladies and 50 males). The imply age on the time of analysis was 69.four years. 100 and forty sufferers (43.1%) had a historical past of malignancy, and 71 sufferers (21.eight%) had undergone pelvic radiation remedy earlier than fracture analysis. Twenty-one sufferers (6.5%) underwent sacroplasty, and the others underwent conservative administration after fracture analysis. The imply follow-up was 51.5 months, and a complete of 101 sufferers died on the ultimate follow-up. The 6-month mortality charge was 9.eight%, the 1-year mortality charge was 17.5%, and the Three-year mortality charge was 25.5%. Intercourse- and age-adjusted standardized mortality ratio (SMR) elevated after fractures. The general SMR is eight.9 at Three months lowering to four.5 at 2 years. Multivariable Cox regression evaluation confirmed that vital elements related to elevated mortality have been male gender, malignancy historical past, lumbosacral fusion with distal fusion stage S1, stroke historical past, low complete femur bone mineral density rating, and low physique mass index.
CONCLUSIONS: Like different forms of osteoporotic fractures, sacral insufficiency fractures are related to elevated mortality.
PMID: 29124468 [PubMed – indexed for MEDLINE]