Mitochondrial protecting and anti-apoptotic results of Rhodiola crenulata extract on hippocampal neurons in a rat mannequin of Alzheimer’s illness.
Neural Regen Res. 2017 Dec;12(12):2025-2034
Authors: Wang JM, Qu ZQ, Wu JL, Chung P, Zeng YS
In our earlier research, we discovered that the edible alcohol extract of the foundation of the medicinal plant Rhodiola crenulata (RCE) improved spatial cognition in a rat mannequin of Alzheimer’s illness. One other research from our laboratory confirmed that RCE enhanced neural cell proliferation within the dentate gyrus of the hippocampus and prevented harm to hippocampal neurons in a rat mannequin of power stress-induced despair. Nevertheless, the mechanisms underlying the neuroprotective results of RCE are unclear. Within the current research, we investigated the anti-apoptotic impact of RCE and its neuroprotective mechanism of motion in a rat mannequin of Alzheimer’s illness established by intracerebroventricular injection of streptozotocin. The rats have been pre-administered RCE at doses of 1.5, three.zero or 6.zero g/kg for 21 days earlier than mannequin institution. ATP and cytochrome c oxidase ranges have been considerably decreased in rats with Alzheimer’s illness. Moreover, neuronal damage was apparent within the hippocampus, with the presence of a lot of apoptotic neurons. Compared, in rats given RCE pretreatment, ATP and cytochrome c oxidase ranges have been markedly elevated, the variety of apoptotic neurons was decreased, and mitochondrial damage was mitigated. The three.zero g/kg dose of RCE had the optimum impact. These findings counsel that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer’s illness.
PMID: 29323042 [PubMed]