Decrease Serum Zinc and Larger CRP Strongly Predict Prenatal Despair and Physio-somatic Signs, Which All Collectively Predict Postnatal Depressive Signs.
Mol Neurobiol. 2017 Mar;54(2):1500-1512
Authors: Roomruangwong C, Kanchanatawan B, Sirivichayakul S, Mahieu B, Nowak G, Maes M
Being pregnant and supply are related to activation of immune-inflammatory pathways which can prime parturients to develop postnatal despair. There are, nevertheless, few information on the associations between immune-inflammatory pathways and prenatal despair and physio-somatic signs. This research examined the associations between serum zinc, C-reactive protein (CRP), and haptoglobin on the finish of time period and prenatal physio-somatic signs (fatigue, again ache, muscle ache, dyspepsia, obstipation) and prenatal and postnatal depressive and nervousness signs as measured utilizing the Edinburgh Postnatal Despair Scale (EPDS), Beck Despair Stock (BDI), Hamilton Despair Ranking Scale (HAMD), and Spielberger’s State Nervousness Stock (STAI). Zinc and haptoglobin have been considerably decrease and CRP elevated on the finish of time period as in contrast with non-pregnant girls. Prenatal despair was predicted by decrease zinc and lifelong historical past of despair, nervousness, and premenstrual rigidity syndrome (PMS). The latter histories have been additionally considerably and inversely associated to decrease zinc. The severity of prenatal EDPS, HAMD, BDI, STAI, and physio-somatic signs was predicted by fatigue within the first and second trimesters, a optimistic life historical past of despair, nervousness, and PMS, and decrease zinc and better CRP. Postnatal depressive signs are predicted by prenatal despair, physio-somatic signs, zinc and CRP. Prenatal depressive and physio-somatic signs have an immune-inflammatory pathophysiology, whereas postnatal depressive signs are extremely predicted by prenatal immune activation, prenatal despair, and a lifetime historical past of despair and PMS. Earlier episodes of despair, nervousness issues, and PMS could prime pregnant females to develop prenatal and postnatal depressive signs through activated immune pathways.
PMID: 26846364 [PubMed – indexed for MEDLINE]