Longitudinal Analysis of Residual Cortical and Subcortical Motor Evoked Potentials in Spinal Twine Injured Rats.
J Neurotrauma. 2016 05 15;33(10):907-16
Authors: Redondo-Castro E, Navarro X, García-Alías G
We’ve utilized transcranial electrical stimulation to rats with spinal twine damage and selectively examined the motor evoked potentials (MEPs) conveyed by descending motor pathways with cortical and subcortical origin. MEPs had been elicited by electrical stimulation to the mind and recorded on the tibialis anterior muscle groups. Stimulation parameters had been characterised and modifications in MEP responses examined in unhurt rats, in rats with delicate or reasonable contusion, and in animals with full transection of the spinal twine. All accidents had been situated on the T8 vertebral stage. Two peaks, termed N1 and N2, had been obtained when altering from single pulse stimulation to trains of 9 pulses at 9?Hz. Selective accidents to the mind or spinal twine funiculi evidenced the subcortical origin of N1 and the cortical origin of N2. Animals with delicate contusion confirmed small behavioral deficits and abolished N1 however maintained small amplitude N2 MEPs. Substantial motor deficits developed in rats with reasonable contusion, and these rats had fully eradicated N1 and N2 MEPs. Animals with full twine transection had abolished N1 and N2 and confirmed extreme impairment of locomotion. The outcomes point out the reliability of MEP testing to longitudinally consider over time the diploma of impairment of cortical and subcortical spinal pathways after spinal twine accidents of various severity.
PMID: 26560177 [PubMed – indexed for MEDLINE]