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Native Remedy of Osteoporotic Sheep Vertebral Physique With Calcium Sulfate for Reducing the Potential Fracture Threat: Microstructural and Biomechanical Evaluations.

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Native Remedy of Osteoporotic Sheep Vertebral Physique With Calcium Sulfate for Reducing the Potential Fracture Threat: Microstructural and Biomechanical Evaluations.

Clin Backbone Surg. 2016 Aug;29(7):E358-64

Authors: Liu D, Wu ZX, Zhang Y, Wang CR, Xie QY, Gong Okay, Zhang B, Quan Y, Pan XM

Summary
STUDY DESIGN: On this examine, calcium sulfate (CS) was injected by means of pedicle into the osteoporotic vertebral physique in vivo in sheep, and micro-computed tomography evaluation, histologic commentary, and biomechanical check had been carried out.
OBJECTIVE: To research the advance on microstructure and biomechanical efficiency of lumbar vertebrae augmented with CS in osteoporotic sheep.
SUMMARY OF BACKGROUND DATA: The current remedies for osteoporosis depends on systemic medicines supposed to extend the bone mineral density (BMD). Though efficient, these time-consuming medicines present little safety from fracture within the “early interval” after initiation of remedy. On this regard, the technique of native remedy is to focus on particular areas of the skeletal system which can be liable to osteoporotic fractures. Nonetheless, there’s little or no analysis targeted on native remedy of osteoporotic vertebrae with CS.
METHODS: Eight feminine sheep had been induced to osteoporosis with bilateral ovariectomy and methylprednisolone administration for 12 months. After profitable institution of an osteoporotic mannequin, lumbar vertebrae (L1-L4) in each sheep had been randomly divided into 2 teams: CS group and management group (2 vertebrae in every group in each sheep). CS was injected into the vertebral physique transpedicularly within the CS group and no remedies had been carried out within the management group. Three months later, all sheep had been killed and all L1-L4 vertebrae had been harvested. Thereafter, microstructure and biomechanical efficiency of the cancellous bone of the vertebral physique had been assessed by means of micro-computed tomography evaluation, histologic commentary, and biomechanical check, respectively.
RESULTS: After a 12-month induction with ovariectomy and methylprednisolone administration, the imply BMD of the sheep lumbar vertebrae considerably decreased (>25%) in contrast with the worth earlier than induction, which demonstrated profitable institution of osteoporosis. Three months after injection of CS, CS was utterly degraded with none stays in bone tissue and the standard of bone tissue (quantity and density of the bone tissue) within the CS group was considerably increased than that within the management group. The last word load, stiffness, and vitality absorption within the CS group had been all considerably increased than these within the management group.
CONCLUSIONS: The preliminary knowledge counsel that native injection of CS can considerably enhance the quantity, density, and biomechanical efficiency of the bone trabeculae in osteoporotic vertebra. The native injection of CS is also used as a brand new technique to enhance the bodily microstructure and increase the mechanical properties in “high-risk” vertebral our bodies, reducing the potential fracture threat of sufferers with osteoporosis. The strict inclusion and exclusion standards ought to be carried out earlier than remedy.

PMID: 25072801 [PubMed – indexed for MEDLINE]

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2022-03-17
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