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Itraconazole remedy in a pancreatic adenocarcinoma affected person: A case report.

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Itraconazole remedy in a pancreatic adenocarcinoma affected person: A case report.

J Oncol Pharm Pract. 2016 Jun;22(three):528-32

Authors: Lockhart NR, Waddell JA, Schrock NE

Summary
OBJECTIVE: To report the case of a affected person receiving itraconazole for the therapy of histoplasmosis and his subsequent discount in pancreatic tumor measurement.
CASE SUMMARY: A 64-year-old male was identified with Stage III regionally superior unresectable pancreatic adenocarcinoma. The affected person was administered radiation plus chemotherapy, which included cisplatin and capecitabine. Upon restaging, the affected person’s tumor was once more decided to be unresectable; due to this fact, palliative chemotherapy therapies have been initiated, which included gemcitabine and erlotinib. After two gemcitabine cycles, he was admitted to the hospital due to lack of motor perform on account of spinal wire hemisection. After the surgical procedure, the affected person grew to become neutropenic due to earlier chemotherapy cycle and developed disseminated histoplasmosis. After he acquired his nine-month course of itraconazole, the pancreatic most cancers was readdressed and he was then deemed to be resectable and had a Whipple process. Over the subsequent a number of years, he confirmed no proof of pancreatic metastases or relapse.
DISCUSSION: Itraconazole has been proven to have many mechanisms by which it might probably suppress tumor cell development, which incorporates inhibition of the Hedgehog pathway, vascular endothelial development issue receptor-2, and P-glycoprotein efflux pump. This azole antifungal has been studied in small affected person populations with varied sorts of cancers. Research of basal cell carcinoma, nonsmall cell lung most cancers, ovarian most cancers, and malignant pleural mesothelioma have proven favorable outcomes suggesting that extra examine of itraconazole is warranted to determine its scientific utility.
CONCLUSION: There would must be way more analysis carried out to find out if this agent had a job as a chemotherapy agent; nevertheless, well being care professionals ought to pay attention to itraconazole’s potential antineoplastic mechanisms.

PMID: 25670260 [PubMed – indexed for MEDLINE]

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