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Is period of preoperative anti-tuberculosis remedy a danger issue for postoperative relapse or non-healing of spinal tuberculosis?

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Is period of preoperative anti-tuberculosis remedy a danger issue for postoperative relapse or non-healing of spinal tuberculosis?

Eur Backbone J. 2016 Dec;25(12):3875-3883

Authors: Ren HL, Jiang JM, Wang JX, Qu DB, Chen JT

PURPOSE: This examine evaluated the connection between spinal TB postoperative recurrence or non-healing and period of preoperative anti-TB remedy (ATT).
METHODS: From January 2004 to January 2013, sufferers who underwent surgical procedure for spinal TB and met this examine’s inclusion standards had been retrospectively reviewed. Noticed parameters had been age, intercourse, preliminary ESR, preoperative ESR, diploma of ESR change, preliminary CRP, preoperative CRP, diploma of CRP change, period of preoperative ATT, surgical method, presence of inside fixation, location of spinal lesion, variety of concerned segments, period of operation, and intraoperative blood loss. The information had been analyzed by univariate and multivariate analyses for spinal TB recurrence or non-healing to find out associated danger components.
RESULTS: A complete of 223 sufferers met the inclusion standards. There have been 84 feminine and 139 male sufferers with a imply age of 42.2 years (vary 2-85 years). The follow-up interval was 18-72 months (common 28.7 months). Amongst 223 sufferers noticed, 23 sufferers had postoperative relapse or non-healing (10.three %) in the course of the follow-up interval. Statistical evaluation indicated that the situation of a spinal lesion was considerably related to postoperative relapse or non-healing. Threat of postoperative relapse or non-healing in thoracolumbar TB was 2.524-fold (95 % CI 1.026-6.580) that of lumbosacral TB.
CONCLUSIONS: Length of preoperative ATT might not be a danger issue for postoperative recurrence or non-healing of spinal TB. Junctional zones such because the lumbosacral and thoracolumbar junction have a better recurrence price than non junctional.

PMID: 26951176 [PubMed – indexed for MEDLINE]

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