Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection.
Muscle Nerve. 2013 Jun 6;
Authors: Hurst RW, Morris JM, Dyck PJ, Bosch EP, Reeves RK
Introduction: Potential benefit from stem cell treatments has more patients seeking treatment without understanding possible risks. Methods and Results: We describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year prior to onset of symptoms. Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen prior to stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. Biopsy of a lumbar dorsal sensory root showed myelinated fiber degeneration and loss, with endoneurial inflammation. The hypertrophic inflammatory cauda equina syndrome was potentially triggered by the prior intrathecal neural stem cell injection. Discussion: Safety of intrathecal stem cell treatments is not routinely regulated in overseas stem cell facilities. We wish to bring this potential complication to the attention of health care providers. © 2013 Wiley Periodicals, Inc.
PMID: 23740462 [PubMed – as supplied by publisher]