In-vivo examine of osseointegration in Status LP cervical disc prosthesis.
BMC Musculoskelet Disord. 2018 Feb 07;19(1):42
Authors: Lou J, Wang B, Wu T, Wu W, Li H, Liu Z, Liu H
BACKGROUND: A examine was designed to quantify the extent of porous osseointegration on the prosthesis-bone interface within the Status LP prosthesis containing a plasma-sprayed titanium coating.
METHODS: Utilizing an anterior surgical method, cervical disc arthroplasty was carried out in eight mature male goats on the C3-C4 phase, adopted by implantation of the Status LP prosthesis. The vertebral specimens have been examined utilizing microcomputed tomograph for histomorphometric quantification, and proceeded by routine paraffin processing for histological commentary. Therefore, the porous osseointegration on the prosthesis-bone interface was evaluated based mostly on histologic and histomorphometric analyses.
RESULTS: At 6 months after surgical procedure, there was no proof of prosthesis migration, loosening, subsidence, or neurologic or vascular issues. Primarily based on gross histologic evaluation, there was wonderful porous ingrowth on the prosthesis-bone interface, with out important histopathologic adjustments. Histomorphometric evaluation on the prosthesis-bone interface indicated the imply porous ingrowth of 48.5%?±?10.four% and the full ingrowth vary of 36.6 to 59.eight%.
CONCLUSIONS: As the primary complete in vivo investigation into the Status LP prosthesis, this challenge established a profitable animal mannequin within the analysis of cervical disc arthroplasty. Furthermore, histomorphometric evaluation of porous ingrowth on the prosthesis-bone interface was extra favorable for cervical disc arthroplasty with the Status LP prosthesis in comparison with historic reviews of appendicular whole joint arthroplasty.
PMID: 29415694 [PubMed – in process]