Influence of H3.three Okay27M Mutation on Prognosis and Survival of Grade IV Spinal Wire Glioma on the Foundation of New 2016 World Well being Group Classification of the Central Nervous System.
Neurosurgery. 2018 Might 01;:
Authors: Yi S, Choi S, Shin DA, Kim DS, Choi J, Ha Y, Kim KN, Suh CO, Chang JH, Kim SH, Yoon DH
BACKGROUND: Spinal twine glioma grade IV is a uncommon, diffuse midline glioma. H3 Okay27M-mutant was labeled in a special entity within the 2016 World Well being Group (WHO) classification just lately. No reviews about prognosis of spinal twine glioma grade IV can be found but.
OBJECTIVE: To investigate the prognostic components for spinal twine glioma grade IV.
METHODS: Twenty-five sufferers with spinal twine glioma of grade IV who underwent surgical procedure in a single institute had been chosen. All grade IV spinal twine glioma histologically confirmed as glioblastoma or “diffuse midline glioma with H3 Okay27M-mutant” by the 2016 WHO classification of the central nervous system had been included. Fundamental demographics, remedy modalities, and pathological tumor molecular profiles had been investigated for prognosis.
RESULTS: Imply age was 39.1 yr; male to feminine ratio was 18 : 7. Tumor was situated in thoracic twine (53.three%), cervical twine (40%), and lumbar space (6.7%). Median total survival was 37.1 mo; median disease-free survival was 18.5 mo. Therapy modality confirmed no statistical distinction. Solely Okay27M profile confirmed important prognostic worth, 20 sufferers (80%) confirmed Okay27M mutation optimistic, Okay27M mutation sufferers confirmed longer total survival (40.07 mo) than Okay27M adverse sufferers (11.63 mo, P < .0001), and disease-free survival (20.85 vs eight.72 mo, P = .0241).
CONCLUSION: This examine is the primary and largest report of the prognosis of major spinal twine grade IV glioma utilizing the brand new WHO classification. This examine reported survival evaluation and prognostic components, and revealed that H3.three Okay27M mutation just isn’t a serious poor prognostic issue. Additional research to discover Okay27M mutations wanted for danger stratification and remedy optimization.
PMID: 29718432 [PubMed – as supplied by publisher]