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Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland

The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue – positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic mamma. Neurons projecting to the last right abdominal mamma were found in L1-L3 DRG. In the present study, the cryostat sections from these ganglia were stained for calcitonin gene-related peptide (CGRP), substance P (SP), nitric oxide synthase (NOS), galanin (GAL) and pituitary adenylate cyclase activating polypeptide (PACAP). Immunohistochemistry revealed that the vast majority of FB+ mammary gland-projecting neurons contained immunoreactivity to CGRP (68.87+/-0.7%), SP (63.4+/-0.9%), NOS (32.47+/-0.9%), GAL (16.28+/-0.8%) and less numerous nerve cells stained for PACAP (5.87+/-0.5%). The present results largely correspond with findings dealing with immunohistochemical characterization of nerve fibres supplying porcine mammary gland structures described earlier

Keywords : analysis,Animals,Calcitonin,Calcitonin Gene-Related Peptide,chemistry,cytology,Female,Galanin,Ganglia,Spinal,Immunohistochemistry,innervation,Mammary Glands,Animal,Neurons,Nitric Oxide,Nitric Oxide Synthase,Pituitary Adenylate Cyclase-Activating Polypeptide,Poland,Substance P,Swine,Universities,veterinary,, Characterisation,Dorsal,Root,Ganglia, local acupuncture clinics

Date of Publication : 2011 Dec

Authors : Franke-Radowiecka A;

Organisation : Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. ameliaf@uwm.edu.pl

Journal of Publication : Histol Histopathol

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21972090

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