Menu
Menu
19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

IDH1 Mutation in Mind Stem Glioma: Case Report and Evaluation of Literature.

Related Articles

IDH1 Mutation in Mind Stem Glioma: Case Report and Evaluation of Literature.

Asian J Neurosurg. 2018 Apr-Jun;13(2):414-417

Authors: Javadi SA, Hartmann C, Walter GF, Banan R, Samii A

Summary
The function of isocitrate dehydrogenase 1 (IDH1) mutation in mind stem glioma is just not clear. To one of the best of our data, six instances of mind stem gliomas carrying IDH1/2 mutations are at present reported within the literature. One case of diffuse mind stem glioma with IDH1 mutation, which was adopted for two years, is introduced and in contrast with IDH1 destructive tumors. A 22-year-old girl was referred with diplopia and left arm palsy. Neuroimaging detected a nonenhancing, nonhomogeneous diffuse infiltrating mind stem tumor extending from pons to medulla. Microsurgical debulking was carried out. Microscopic analysis of the tissue specimen and immunohistochemistry revealed an astrocytoma WHO Grade II with proliferation charge of three% and glial fibrillary acidic protein (GFAP)-positive tumor cells. Apparently, the tumor cells expressed mutated IDH1 R132H protein. The affected person underwent adjuvant radiation and chemotherapy. The first and a couple of years’ scientific/radiological traits didn’t point out any vital distinction from different instances with out IDH1 mutation. the prognostic worth of IDH1/2 mutation in mind stem glioma is unclear. Mind stem biopsies could enable willpower of a tissue-based tumor prognosis for additional investigations.

PMID: 29682047 [PubMed]

Share to care...

Share on facebook
Facebook
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on google
Google+
Share on linkedin
LinkedIn
Share on skype
Skype

What we do...

The Harley Street Hospital

Testimonials

What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......