19 Harley St, London, W1G 9QJ, UK

High whole-body bone mineral density in ossification of the posterior longitudinal ligament – Lumbar Spinal Stenosis

The article investigates whether patients with ossification of the posterior longitudinal ligament (OPLL) develop increased whole-body bone mineral density (BMD). The study collected data from Japanese patients with symptomatic OPLL and a control group without spinal ligament ossification. Demographic data and whole-body BMD measurements were collected from all participants. The results show that patients with OPLL have increased whole-body BMD regardless of sex, suggesting that OPLL is associated with a systemic pathology. Factors associated with increased BMD include age, BMI, and the presence of diffuse or localized OPLL. Overall, the study highlights the association between OPLL and systemic metabolic disturbances

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most experienced spinal facility on Harley Street UK

Published article

CONCLUSIONS: Patients with OPLL have increased whole-body BMD regardless of sex, indicating that it is not simply due to load-bearing from obesity. These findings suggested that OPLL is associated with a systemic pathology.

Lumbar Decompression Surgery Expert. Best Spinal Surgeon UK
Spine J. 2023 Jul 10:S1529-9430(23)03254-0. doi: 10.1016/j.spinee.2023.06.400. Online ahead of print.ABSTRACTBACKGROUND CONTEXT: Recent studies suggest that ossification of the posterior longitudinal ligament (OPLL) is exacerbated by systemic metabolic disturbances, including obesity. However, although an increase in bone mineral density (BMD) measured at the lumbar spine has been reported in patients with OPLL, no studies have,

Spine J. 2023 Jul 10:S1529-9430(23)03254-0. doi: 10.1016/j.spinee.2023.06.400. Online ahead of print.

ABSTRACT

BACKGROUND CONTEXT: Recent studies suggest that ossification of the posterior longitudinal ligament (OPLL) is exacerbated by systemic metabolic disturbances, including obesity. However, although an increase in bone mineral density (BMD) measured at the lumbar spine has been reported in patients with OPLL, no studies have investigated the systemic BMD of patients with OPLL in detail.

PURPOSE: We investigated whether patients with OPLL develop increased whole-body BMD.

STUDY DESIGN: Single institution cross-sectional study.

PATIENT SAMPLE: Data were collected from Japanese patients with symptomatic OPLL (OPLL [+]; n = 99). Control data (OPLL [-]; n = 226) without spinal ligament ossification were collected from patients who underwent spinal decompression, spinal fusion, or hip replacement surgery.

OUTCOME MEASURES: Demographic data, including age, body mass index (BMI), comorbidities, history of treatment for osteoporosis, and history of vertebral and non-vertebral fractures, was obtained from all participants. In addition, whole-body BMD, including the lumbar spine, thoracic spine, femoral neck, skull, ribs, entire upper extremity, entire lower extremity, and pelvis, were measured in all participants using whole-body dual-energy X-ray absorptiometry (DXA).

METHODS: Patient data were collected from 2018 to 2022. All participants were categorized based on sex, age (middle-aged [<70 years] and older adults [≥70 years]), and OPLL type (localized OPLL [OPLL only in the cervical spine], diffuse OPLL [OPLL in regions including the thoracic spine]), and OPLL [-]) and each parameter was compared. The factors associated with whole-body BMD were evaluated via multivariable linear regression analysis.

RESULTS: Compared with the OPLL (-) group, the OPLL (+) group of older women had significantly higher BMD in all body parts (P <0.01), and the OPLL (+) group of older men had significantly higher BMD in all body parts except the ribs, forearm, and skull (P <0.01). The factors associated with increased BMD of both the femoral neck (load-bearing bone) and skull (non-load-bearing bone) were age, BMI, and co-existing diffuse OPLL in women and BMI and co-existing localized OPLL in men.

CONCLUSIONS: Patients with OPLL have increased whole-body BMD regardless of sex, indicating that it is not simply due to load-bearing from obesity. These findings suggested that OPLL is associated with a systemic pathology.

PMID:37437695 | DOI:10.1016/j.spinee.2023.06.400

The London Spine Unit : most experienced spinal facility on Harley Street UK

Read the original publication:

High whole-body bone mineral density in ossification of the posterior longitudinal ligament

Related Posts

0/5 (0 Reviews)

Trusindex Reviews

London Spine Unit Harley Street Hospital

A Focus on High Quality Specialised Care

We are a specialist Private Hospital based on Harley Street, London UK The Harley Street Hospital, Day Surgery Hospital

We provide exclusive health services for individuals seeking Advanced medical, non-surgical or minimally invasive treatments. We are covered by All Insurance Companies apart from AXA PPP

Our Medical Director and Lead Spinal Surgeon Mr Mo Akmal MD is a world renowned Spine Specialist Consultant with over 20 years of experience. He and his team have developed revolutionary techniques to perform all types of Spinal Surgery as a Day Case procedure without traditional General Anaesthetic.

We are constantly improving our techniques for treatment and improving facilities for our patients.

Book your Appointment Now 
Check out our Reviews 
Check out our Patient Videos 
Check our Mr Akmal’s Profile

 

What our patients say ...

Spine J. 2023 Jul 10:S1529-9430(23)03254-0. doi: 10.1016/j.spinee.2023.06.400. Online ahead of print.ABSTRACTBACKGROUND CONTEXT: Recent studies suggest that ossification of the posterior longitudinal ligament (OPLL) is exacerbated by systemic metabolic disturbances, including obesity. However, although an increase in bone mineral density (BMD) measured at the lumbar spine has been reported in patients with OPLL, no studies have

Revolutionary Keyhole surgical technique to vaporise bulging discs

Dr Mo Akmal Medical Director
Dr Mo Akmal MD - Lead Spinal Surgeon

Laser Disc Surgery can be performed under local anaesthetic at The Harley Street Hospital.

Initial Consultation

with Consultant Spine Surgeon
£ 250
  • No Waiting Times
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion
  • Review of Previous Scans and Reports

Follow up Consultation

any appointment after initial consultation
£ 180
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion

High Resolution MRI Scan

any Single Region (3.0 Tesla)
£ 600
  • No waiting times
  • Includes Full Radiologist Report
  • Open or Closed MRI scan types
  • Copy of Scan on CD

Website Offer

Pre-Booked Online
£1130
£ 800
  • Initial Consultation
  • MRI Scan (Single Region)
  • Follow Up consultation
  • Same Day One Stop Visit
  • Full Medical and MRI scan Report
  • Copy of scan on CD
Popular

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810