Excessive frequency of vertebral fracture and low bone high quality in sufferers with rheumatoid arthritis-Outcomes from TOMORROW examine.
Mod Rheumatol. 2017 Could;27(three):398-404
Authors: Okano T, Inui Okay, Tada M, Sugioka Y, Mamoto Okay, Wakitani S, Koike T, Nakamura H
OBJECTIVES: Osteoporosis is without doubt one of the problems in sufferers with rheumatoid arthritis (RA). On this examine, we researched the morbidity of current vertebral fractures and the chance elements for vertebral fractures in sufferers with RA.
METHODS: This examine included 413 contributors, 208 sufferers with RA, and 205 age- and sex-matched controls with out RA. Scientific knowledge, radiographic evaluation of vertebral fracture from T4 to L4 in thoracic and lumber backbone, bone mineral density (BMD), and bone metabolic markers (BMM) have been analyzed.
RESULTS: Vertebral fractures have been noticed extra continuously, extreme and a number of in sufferers with RA. Within the logistic regression evaluation, age (adjusted odds ratios (OR): 1.07, 95% confidence interval (CI): 1.04-1.09) and RA (adjusted OR: 1.72, 95% CI: 1.04-2.83) have been threat elements for current vertebral fracture. Furthermore, two bone matrix-related markers, undercarboxylated osteocalcin (ucOC) (adjusted OR: 1.68, 95% CI: 1.02-2.78), and urinary pentocidine (adjusted OR: 2.51, 95% CI: 1.48-Four.24) have been related to current vertebral fracture.
CONCLUSIONS: Excessive frequent, a number of, and extreme vertebral fractures have been present in sufferers with RA in comparison with the controls. Low bone high quality is perhaps the reason for the frequent prevalence of vertebral fracture in sufferers with RA.
PMID: 27484855 [PubMed – indexed for MEDLINE]