Herpes simplex encephalitis (HSE) is a rare complication of neurosurgical procedures but must be considered in early deterioration of the postoperative patient. This is the first report of HSE following spinal cord tumor resection. A 65-year-old woman had C2-C5 laminectomy for subtotal resection of intramedullary ependymoma. Six days postoperatively she developed fever, vomiting and rapid decline in mental status. Brain MRI revealed enhancement of left insular cortex. Polymerase chain reaction on cerebrospinal fluid (CSF) identified herpes simplex virus type 1 (HSV-1) as the causal agent. Twenty-one days of acyclovir led to improvement. Three subsequent admissions to neurological intensive care unit were required for deterioration in mental status, including pneumonia, hydrocephalus and deep vein thromboses. Ventriculoperitoneal shunt (VPS), tracheotomy, percutaneous intravenous central catheter (PICC) line and percutaneous endoscopic gastrostomy (PEG) were placed. She was discharged to skilled nursing home care. Acyclovir is effective therapy against HSV, though outcomes may be poor even in optimally treated cases. Empiric treatment must be started even in the absence of serologic evidence of HSV infection if suspicion for HSE is high
Keywords : adverse effects,Aged,Brain,cerebrospinal fluid,Encephalitis,Herpes Simplex,Ependymoma,etiology,Female,Fever,Gastrostomy,Herpes Simplex,Humans,Hydrocephalus,Infection,Laminectomy,Magnetic Resonance Imaging,methods,Neurosurgical Procedures,nursing,Pneumonia,Polymerase Chain Reaction,Spinal Cord,Spinal Neoplasms,surgery,therapy,Tracheotomy,Universities,Ventriculoperitoneal Shunt,Vomiting,, Simplex,Encephalitis,Following,Spinal,Ependymoma, acupuncture for pain relief
Date of Publication : 2011 Jul
Authors : Raper DM;Wong A;McCormick PC;Lewis LD;
Organisation : Graduate Medical Program, University of Sydney, Level 7, Kolling Building, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia. drap7157@uni.sydney.edu.au
Journal of Publication : J Neurooncol
Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/20941525
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