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Glycosaminoglycan chemical trade saturation switch in human lumbar intervertebral discs: Impact of saturation pulse and relationship with low again ache.
J Magn Reson Imaging. 2017 Mar;45(three):863-871
Authors: Wada T, Togao O, Tokunaga C, Funatsu R, Yamashita Y, Kobayashi Okay, Nakamura Y, Honda H
Summary
PURPOSE: To judge the dependence of saturation pulse energy and period on glycosaminoglycan chemical trade saturation switch (gagCEST) imaging and assess the degeneration of human lumbar intervertebral discs (IVDs) utilizing this technique.
MATERIALS AND METHODS: All photographs had been acquired on a 3T magnetic resonance imaging (MRI) scanner. The CEST results had been measured within the glycosaminoglycan (GAG) phantoms with completely different concentrations. Within the human examine, CEST results had been measured within the nucleus pulposus of IVD. We in contrast the CEST results among the many completely different saturation pulse powers (Zero.four, Zero.eight, and 1.6 ?T) or durations (Zero.5, 1.Zero, and a pair of.Zero sec) at every Pfirrmann grade (I-V). The connection between the CEST results and low again ache was additionally evaluated.
RESULTS: The phantom examine confirmed excessive correlations between the CEST results and GAG focus (R2 ?=?Zero.863, P < Zero.0001, linear regression). Within the human examine, the CEST impact obtained with the Zero.eight ?T energy was considerably higher than these obtained with Zero.four (P < Zero.01) and 1.6 ?T energy (P < Zero.05) at Pfirrmann grade I. The CEST impact obtained with a 1.Zero-sec period was considerably higher than these derived with Zero.5 and a pair of.Zero sec (P < Zero.01) durations at Pfirrmann grades I and II. The CEST results within the group with reasonable low again ache had been considerably decrease than these within the teams with out ache (P < Zero.Zero01) and with delicate ache (P?=?Zero.0216).
CONCLUSION: The distinction of gagCEST imaging within the lumbar IVDs different with saturation pulse energy and period. GagCEST imaging could function a device for evaluating IVD degeneration within the lumbar backbone.
LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:863-871.
PMID: 27439061 [PubMed – indexed for MEDLINE]