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Giant Myxopapillary Ependymoma with Multi-Site Neural Axis Metastases: A Rare Case with Suboptimal Outcome – Lumbar Spinal Stenosis

The article discusses a case of myxopapillary ependymoma, which is a rare tumor that primarily occurs in the spinal cord. The case involves a 44-year-old male patient who presented with non-specific lower back pain persisting for two years. MRI revealed a large tumor in the lumbar spine, invading the sacral bone and presacral tissue. Biopsy confirmed the diagnosis of myxopapillary ependymoma, and surgical resection was performed along with radiation therapy. However, the patient experienced neurological deficits and required physiotherapy after surgery. Follow-up MRI showed tumor growth and metastases along the neural axis. The article emphasizes the importance of complete surgical excision, but highlights the risk of recurrence and recommends radiotherapy. Additionally, it emphasizes the need for preoperative imaging to assess the possibility of metastases

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : best recognised spinal clinic in UK

Published article

BACKGROUND Myxopapillary ependymoma is a rare type of slow-growing tumor that mainly occurs in the spinal cord, particularly in the region of the conus medullaris and the cauda equina. It originates from the ependymal glial cells found in the filum terminale. CASE REPORT We present a clinical case of a 44-year-old male patient who presented with symptoms of non-specific pain in the lower back persisting for the past 2 years. He did not report any specific neurological deficits or radicular…

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Am J Case Rep. 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392.ABSTRACTBACKGROUND Myxopapillary ependymoma is a rare type of slow-growing tumor that mainly occurs in the spinal cord, particularly in the region of the conus medullaris and the cauda equina. It originates from the ependymal glial cells found in the filum terminale. CASE REPORT We present a clinical,

Am J Case Rep. 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392.

ABSTRACT

BACKGROUND Myxopapillary ependymoma is a rare type of slow-growing tumor that mainly occurs in the spinal cord, particularly in the region of the conus medullaris and the cauda equina. It originates from the ependymal glial cells found in the filum terminale. CASE REPORT We present a clinical case of a 44-year-old male patient who presented with symptoms of non-specific pain in the lower back persisting for the past 2 years. He did not report any specific neurological deficits or radicular symptoms. Unenhanced MRI of the lumbar spine showed a giant intradural, extramedullary, heterogenous, expansive tumor at the level L1-S4 with erosion of the sacral bone and invasion of presacral tissue. Based on its characteristic localization and growth pattern, suspicion arose for myxopapillary ependymoma. Biopsy confirmed the initial diagnosis. Partial resection of the tumor with laminectomy and laminoplasty was deemed necessary. Preoperative neural axis MRI showed contrast-enhancing lesions in the cerebellum and the cervical and thoracic spine; therefore, adjuvant radiation therapy was administered. Following the surgery, the patient experienced intermittent episodes of neurological deficits and required physiotherapy. Control MRI a year after the operation showed tumor growth and more metastases along the neural axis. CONCLUSIONS Complete surgical excision of the tumor is the preferred treatment approach, but there is a risk of recurrence even after total excision, so radiotherapy is recommended to minimize the risk of recurrence. Prior to surgery, it is essential to conduct MRI/PET/CT of the head and spine to assess the possibility of metastases.

PMID:38291726 | DOI:10.12659/AJCR.942392

The London Spine Unit : best recognised spinal clinic in UK

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Giant Myxopapillary Ependymoma with Multi-Site Neural Axis Metastases: A Rare Case with Suboptimal Outcome

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Am J Case Rep. 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392.ABSTRACTBACKGROUND Myxopapillary ependymoma is a rare type of slow-growing tumor that mainly occurs in the spinal cord, particularly in the region of the conus medullaris and the cauda equina. It originates from the ependymal glial cells found in the filum terminale. CASE REPORT We present a clinical

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