Live Video Consultation
19 Harley St, London, W1G 9QJ, UK

Big Cell Ependymoma of Lateral Ventricle: Case Report, Literature Evaluate, and Evaluation of Prognostic Elements and Genetic Profile.

Related Articles

Big Cell Ependymoma of Lateral Ventricle: Case Report, Literature Evaluate, and Evaluation of Prognostic Elements and Genetic Profile.

World Neurosurg. 2017 Dec;108:997.e9-997.e14

Authors: Takami H, Graffeo CS, Perry A, Raghunathan A, Jenkins RB, Giannini C, Burns TC

BACKGROUND: Big cell ependymoma (GCE) is a uncommon major central nervous system neoplasm. We report a case of GCE arising within the lateral ventricle.
CASE DESCRIPTION: A 22-year-old feminine offered with generalized seizures. Magnetic resonance imaging demonstrated a diffuse, nonenhancing, multicystic mass centered within the atrium of the appropriate lateral ventricle with extension all through the frontal and temporal horns. An preliminary subtotal resection yielded the signature biphasic sample of GCE. The dominant part contained pleomorphic, bizarre-appearing big cells with low mitotic index, and a minor part comprised monomorphic, extremely mobile, mitotically energetic cells that fashioned perivascular pseudorosettes. Array-comparative genomic hybridization confirmed copy quantity abnormalities in line with chromosomal instability with out proof of RELA- or YAP1-fusion-features most frequently seen in posterior fossa ependymoma group B. Given expectedly poor radiation sensitivity, a second-look surgical procedure was undertaken to attenuate residual earlier than proton beam radiotherapy.
LITERATURE REVIEW: Evaluate of the literature recognized 28 reported instances, with a median age of 34 and bimodal peaks at roughly 20 and 50 years of age, together with 9 supratentorial, 5 infratentorial, and 15 spinal ependymomas. Two infratentorial instances concerned the fourth ventricle; no instances arose from the third or lateral ventricles. Supratentorial tumors predominated in youthful sufferers, whereas different places have been noticed amongst older sufferers (21.6 vs. 46.three years of age; P = zero.01). Instances with Ki-67 index ?10% confirmed worse progression-free survival than these of <10% (P = zero.049).
CONCLUSION: Though uncommon, GCE must be thought-about within the differential of younger sufferers with atypical intraventricular lesions, notably provided that extent of resection is related to elevated survival and GCE is regarded as radiation resistant.

PMID: 28943417 [PubMed – indexed for MEDLINE]

Big Cell Ependymoma of Lateral Ventricle Case Report, Literature Evaluate, and Evaluation of Prognostic Elements and Genetic Profile | Back pain harley street

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810