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Genetic polymorphisms related to the danger of concussion in 1056 faculty athletes: a multicentre potential cohort examine.
Br J Sports activities Med. 2018 Feb;52(three):192-198
Authors: Terrell TR, Abramson R, Barth JT, Bennett E, Cantu RC, Sloane R, Laskowitz DT, Erlanger DM, McKeag D, Nichols G, Valentine V, Galloway L
Summary
BACKGROUND/AIM: To guage the affiliation of genetic polymorphisms APOE, APOE G-219T promoter, microtubule related protein(MAPT)/tau exon 6 Ser53Professional, MAPT/tau Hist47Tyr, IL-6572?G/C and IL-6RAsp358Ala with the danger of concussion in faculty athletes.
METHODS: A 23-centre potential cohort examine of 1056 faculty athletes with genotyping was accomplished between August 2003 and December 2012. All athletes accomplished baseline medical and concussion questionnaires, and post-concussion knowledge had been collected for athletes with a documented concussion.
RESULTS: The examine cohort consisted of 1056 athletes of imply±SD age 19.7±1.5 years, 89.three% male, 59.four% Caucasian, 35.zero% African-American, 5.6% different race. The athletes participated in American soccer, soccer, basketball, softball, males’s wrestling and membership rugby. A complete of 133 (12.1% prevalence) concussions occurred throughout a median surveillance of three years per athlete. We noticed a big optimistic affiliation between IL-6R CC (p=zero.001) and a unfavourable affiliation between APOE4 (p=zero.03) and the danger of concussion. Unadjusted and adjusted logistic regression evaluation confirmed a big affiliation between IL-6R CC and concussion (OR three.48; 95% CI 1.58 to 7.65; p=zero.002) and between the APOE4 allele and concussion (OR zero.61; 95% CI zero.38 to zero.96; p=zero.04), which persevered after adjustment for confounders.
CONCLUSIONS: IL-6R CC was related to a 3 times larger concussion threat and APOE4 with a 40% decrease threat.
PMID: 28918391 [PubMed – indexed for MEDLINE]