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Generalized annular granuloma related to topped dens syndrome, which resolved with colchicine remedy.

Clin Exp Dermatol. 2016 Aug;41(6):640-2

Authors: Cozzani E, Basso D, Cimmino MA, Larosa M, Burlando M, Rongioletti F, Drago F, Parodi A

Summary
Granuloma annulare (GA) is a power, benign, and normally self-limiting cutaneous inflammatory illness, sometimes characterised by small, localized, skin-coloured papules which can be normally asymptomatic or mildly pruriginous. Its aetiopathogenesis remains to be unknown and coverings are hardly ever efficient. Usually, 50-70% of localized GA circumstances are self-limiting and present spontaneous decision after 1-2 years, whereas disseminated GA is much less prone to disappear with out remedy. Therapy of generalized GA is normally based mostly on single case reviews, and just a few research involving giant case collection have been printed. We current the case of a affected person affected by generalized GA, which resolved after colchicine remedy used for concomitant topped dens syndrome attributable to calcium pyrophosphate deposition illness (CPPD). Colchicine might have labored by a direct motion on GA or, alternatively, by controlling CPPD, as a potential set off. Because the low-dosage colchicine remedy was nicely tolerated by our affected person, this may very well be simply used within the administration of GA. Nonetheless, additional research are wanted to substantiate the motion of colchicine on GA.

PMID: 27335228 [PubMed – indexed for MEDLINE]