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Generalized annular granuloma related to topped dens syndrome, which resolved with colchicine therapy.

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Generalized annular granuloma related to topped dens syndrome, which resolved with colchicine therapy.

Clin Exp Dermatol. 2016 Aug;41(6):640-2

Authors: Cozzani E, Basso D, Cimmino MA, Larosa M, Burlando M, Rongioletti F, Drago F, Parodi A

Summary
Granuloma annulare (GA) is a persistent, benign, and normally self-limiting cutaneous inflammatory illness, sometimes characterised by small, localized, skin-coloured papules which are normally asymptomatic or mildly pruriginous. Its aetiopathogenesis continues to be unknown and coverings are hardly ever efficient. Usually, 50-70% of localized GA instances are self-limiting and present spontaneous decision after 1-2 years, whereas disseminated GA is much less prone to disappear with out therapy. Remedy of generalized GA is normally primarily based on single case stories, and just a few research involving giant case sequence have been printed. We current the case of a affected person affected by generalized GA, which resolved after colchicine therapy used for concomitant topped dens syndrome attributable to calcium pyrophosphate deposition illness (CPPD). Colchicine could have labored by a direct motion on GA or, alternatively, by controlling CPPD, as a attainable set off. Because the low-dosage colchicine therapy was nicely tolerated by our affected person, this might be simply used within the administration of GA. Nonetheless, additional research are wanted to substantiate the motion of colchicine on GA.

PMID: 27335228 [PubMed – indexed for MEDLINE]

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