FRAX-based Estimates of 10-year Chance of Hip and Main Osteoporotic Fracture Amongst Adults Aged 40 and Over: United States, 2013 and 2014.
Natl Well being Stat Report. 2017 Mar;(103):1-16
Authors: Looker AC, Sarafrazi Isfahani N, Fan B, Shepherd JA
BACKGROUND: The FRAX algorithm estimates the 10-year chance of hip and main osteoporotic (scientific backbone, forearm, hip, or humerus) fracture for adults aged 40 and over. An skilled panel developed standards to outline elevated FRAX possibilities for U.S. adults aged 50 and over. This report makes use of FRAX estimates from the Nationwide Well being and Diet Examination Survey 2013-2014 to explain the hip and main osteoporotic fracture chance distribution (for adults aged 40 and over) and prevalence of elevated possibilities (for adults aged 50 and over) in america.
METHODS: FRAX U.S. model three.05 was used to calculate fracture chance from danger elements that have been measured (i.e., femur neck bone mineral density, top, and weight) or self-reported (i.e., fracture historical past, glucocorticoid use, rheumatoid arthritis, smoking, and alcohol consumption). Amongst adults aged 50 and over, elevated possibilities have been outlined as three% or larger for hip fracture and 20% or larger for main osteoporotic fracture.
RESULTS: Imply skew-adjusted fracture possibilities have been zero.5% for hip fracture and 5.three% for main osteoporotic fracture amongst adults aged 40 and over, and zero.9% and seven.four%, respectively, amongst adults aged 50 and over. The chances of adults aged 50 and over with an elevated hip or main osteoporotic fracture chance have been 19% and eight%, respectively. Fracture possibilities assorted considerably by age (older teams had larger possibilities than youthful teams), intercourse (ladies had larger possibilities than males), and race and Hispanic origin (non-Hispanic white individuals had larger possibilities than all different race and Hispanic teams) (p < zero.001). An estimated 95%-97% of adults aged 50 and over with an elevated chance of both fracture kind had femoral neck osteoporosis or low bone mass.
CONCLUSIONS: Imply hip and main osteoporotic fracture possibilities have been zero.5% and 5.three%, respectively, for adults aged 40 and over. Amongst adults aged 50 and over, imply hip and main osteoporotic fracture possibilities have been zero.9% (19% with elevated values) and seven.four% (eight% with elevated values), respectively.
PMID: 28459415 [PubMed – indexed for MEDLINE]