Frailty and bone well being in European males.
Age Ageing. 2017 Jul 01;46(four):635-641
Authors: Cook dinner MJ, Oldroyd A, Pye SR, Ward KA, Gielen E, Ravindrarajah R, Adams JE, Lee DM, Bartfai G, Boonen S, Casanueva F, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula Ok, Lean ME, Pendleton N, Punab M, Vanderschueren D, Wu FC, O’Neill TW, EMAS Research Group
Background: frailty is related to an elevated threat of fragility fractures. Much less is thought, nonetheless, in regards to the affiliation between frailty and bone well being.
Strategies: males aged 40-79 years have been recruited from inhabitants registers in eight European centres for participation within the European Male Growing older Research. Topics accomplished a complete evaluation which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA). Frailty was outlined based mostly on an adaptation of Fried’s phenotype standards and a frailty index (FI) was constructed. The affiliation between frailty and the QUS and DXA parameters was decided utilizing linear regression, with changes for age, physique mass index and centre.
Outcomes: in complete, three,231 topics contributed information to the evaluation. Utilizing the Fried categorisation of frailty, pre-frail and frail males had considerably decrease pace of sound (SOS), broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) in comparison with sturdy males (P< zero.05). Comparable outcomes have been seen utilizing the FI after categorisation into ‘excessive’, ‘medium’ and ‘low’ ranges of frailty. Utilizing the Fried categorisation, frail males had decrease femoral neck bone mineral density (BMD) in comparison with sturdy males (P < zero.05), however not decrease lumbar backbone BMD. Utilizing the FI categorisation, a ‘excessive’ stage of frailty (FI > zero.35) was related to decrease lumbar backbone BMD (P < zero.05) when in comparison with these with low (FI < zero.2), however not decrease femoral neck BMD. When analysed as a steady variable, greater FI was linked with decrease SOS, BUA and QUI (P < zero.05).
Conclusions: optimisation of bone well being in addition to prevention of falls needs to be thought-about as methods to scale back fractures in frail older individuals.
PMID: 27852598 [PubMed – indexed for MEDLINE]