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Feasibility of Lumbar Puncture within the Research of Cerebrospinal Fluid Biomarkers for Alzheimer’s Illness in Topics with Down Syndrome.
J Alzheimers Dis. 2017;55(four):1489-1496
Authors: Carmona-Iragui M, Santos T, Videla S, Fernández S, Benejam B, Videla L, Alcolea D, Blennow Okay, Blesa R, Lleó A, Fortea J
Summary
BACKGROUND: Alzheimer’s illness (AD) is the principle medical downside in older adults with Down syndrome (DS). Research of cerebrospinal fluid (CSF) AD biomarkers are restricted and the feasibility of lumbar puncture (LP) is controversial on this inhabitants.
OBJECTIVE: To research the frequency of problems after a LP in DS.
METHODS: We collected information from 80 adults with DS that underwent a LP inside the Down Alzheimer Barcelona Neuroimaging Initiative. Demographics, cognitive standing, headache historical past, and presence of problems after the LP have been recorded in each topic. In 53 of them (lively group), this info was collected following a semi-structured and validated protocol that actively seems for problems. Different variables associated to the LP process have been additionally recorded. A phone interview to the caregiver was carried out 5-7 days after the process to ask about problems. Knowledge from 27 topics (medical observe group), from whom the presence of problems was obtained in a medical follow-up go to inside the three months after the LP, have been additionally included.
RESULTS: There have been no antagonistic occasions in 90% of our individuals. Probably the most frequent complication was headache (6.25%); just one topic reported a typical post-lumbar puncture headache with reasonable severity that required analgesic therapy. Dizziness (three.75%) and again ache (1.25%) have been additionally reported. All of the individuals that reported problems belonged to the lively group.
CONCLUSION: LP will be safely carried out to review CSF biomarkers in DS. The reported problems are qualitatively much like the final inhabitants, however are much less incessantly reported, even when actively looked for.
PMID: 27858714 [PubMed – indexed for MEDLINE]