19 Harley St, London, W1G 9QJ, UK

FDG-PET/CT-guided biopsy of bone metastases sets a new course in patient management after extensive imaging and multiple futile biopsies

A 73-year-old man with a history of prostate and bladder carcinoma and persistent back pain was diagnosed by MRI with multiple vertebral metastases including a compression fracture of T7. He received radiotherapy for pain relief and for vertebral instability with incipient spinal stenosis, but additional targeted systemic therapy was intended. Therefore, multiple attempts at minimally invasive and open biopsies for histological characterisation of the bone metastases were performed, but failed to provide a conclusive specimen, although CT, MRI and bone scintigraphy were used for biopsy planning. Only histopathological analysis of an (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT-guided additional biopsy at a site with high metabolic activity yielded the final diagnosis of bone metastases of a neuroendocrine small cell cancer of unknown origin; hence, the patient had a third malignancy requiring a different therapy regimen and diagnostic work-up

Keywords : Adenocarcinoma,Aged,analysis,Back,Back Pain,Biopsy,Carcinoma,Carcinoma,Small Cell,Carcinoma,Transitional Cell,diagnosis,diagnostic imaging,Fluorodeoxyglucose F18,Germany,history,Humans,Male,methods,Neoplasms,Unknown Primary,Neuroendocrine Tumors,Pain,pathology,Positron-Emission Tomography,Prostatic Neoplasms,Radiology,Radiopharmaceuticals,radiotherapy,secondary,Spinal Neoplasms,Spinal Stenosis,Spine,therapy,Tomography,X-Ray Computed,Urinary Bladder Neoplasms,, Biopsy,Bone,Metastases,Sets, neck pain clinic london

Date of Publication : 2011 Mar

Authors : Werner MK;Aschoff P;Reimold M;Pfannenberg C;

Organisation : Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Medical Center, Tubingen, Germany. [email protected]

Journal of Publication : Br J Radiol

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21325361

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Primary spinal melanoma a case report and literature review | Nerve specialist near me

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810